CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-008510
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Low affinity cationic amino acid transporter 2 
Protein Synonyms/Alias
 CAT-2; CAT2; Solute carrier family 7 member 2 
Gene Name
 SLC7A2 
Gene Synonyms/Alias
 ATRC2; CAT2 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
29LDSLEDTKLCRCLSTubiquitination[1, 2]
226KISEEFLKNISASARubiquitination[3]
449QPKCSPEKDGLGSSPubiquitination[1, 2]
461SSPRVTSKSESQVTMubiquitination[1, 2, 3, 4, 5, 6]
632VHAAAEEKSAIQANDubiquitination[1, 2, 3, 5]
654SPFIFHEKTSEF***ubiquitination[1, 2, 3]
Reference
 [1] Ubiquitin ligase substrate identification through quantitative proteomics at both the protein and peptide levels.
 Lee KA, Hammerle LP, Andrews PS, Stokes MP, Mustelin T, Silva JC, Black RA, Doedens JR.
 J Biol Chem. 2011 Dec 2;286(48):41530-8. [PMID: 21987572]
 [2] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661]
 [3] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [4] A data set of human endogenous protein ubiquitination sites.
 Shi Y, Chan DW, Jung SY, Malovannaya A, Wang Y, Qin J.
 Mol Cell Proteomics. 2011 May;10(5):M110.002089. [PMID: 20972266]
 [5] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094]
 [6] Proteome-wide identification of ubiquitylation sites by conjugation of engineered lysine-less ubiquitin.
 Oshikawa K, Matsumoto M, Oyamada K, Nakayama KI.
 J Proteome Res. 2012 Feb 3;11(2):796-807. [PMID: 22053931] 
Functional Description
 Low-affinity, high capacity permease involved in the transport of the cationic amino acids (arginine, lysine and ornithine). Plays a regulatory role in classical or alternative activation of macrophages (By similarity). 
Sequence Annotation
 MOD_RES 455 455 Phosphoserine.
 MOD_RES 646 646 Phosphoserine.
 CARBOHYD 157 157 N-linked (GlcNAc...) (Potential).
 CARBOHYD 227 227 N-linked (GlcNAc...) (Potential).
 CARBOHYD 239 239 N-linked (GlcNAc...) (Potential).  
Keyword
 Alternative splicing; Amino-acid transport; Complete proteome; Glycoprotein; Membrane; Phosphoprotein; Polymorphism; Reference proteome; Transmembrane; Transmembrane helix; Transport. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 658 AA 
Protein Sequence
MIPCRAALTF ARCLIRRKIV TLDSLEDTKL CRCLSTMDLI ALGVGSTLGA GVYVLAGEVA 60
KADSGPSIVV SFLIAALASV MAGLCYAEFG ARVPKTGSAY LYTYVTVGEL WAFITGWNLI 120
LSYVIGTSSV ARAWSGTFDE LLSKQIGQFL RTYFRMNYTG LAEYPDFFAV CLILLLAGLL 180
SFGVKESAWV NKVFTAVNIL VLLFVMVAGF VKGNVANWKI SEEFLKNISA SAREPPSENG 240
TSIYGAGGFM PYGFTGTLAG AATCFYAFVG FDCIATTGEE VRNPQKAIPI GIVTSLLVCF 300
MAYFGVSAAL TLMMPYYLLD EKSPLPVAFE YVGWGPAKYV VAAGSLCALS TSLLGSIFPM 360
PRVIYAMAED GLLFKCLAQI NSKTKTPIIA TLSSGAVAAL MAFLFDLKAL VDMMSIGTLM 420
AYSLVAACVL ILRYQPGLSY DQPKCSPEKD GLGSSPRVTS KSESQVTMLQ RQGFSMRTLF 480
CPSLLPTQQS ASLVSFLVGF LAFLVLGLSV LTTYGVHAIT RLEAWSLALL ALFLVLFVAI 540
VLTIWRQPQN QQKVAFMVPF LPFLPAFSIL VNIYLMVQLS ADTWVRFSIW MAIGFLIYFS 600
YGIRHSLEGH LRDENNEEDA YPDNVHAAAE EKSAIQANDH HPRNLSSPFI FHEKTSEF 658 
Gene Ontology
 GO:0005737; C:cytoplasm; IDA:HPA.
 GO:0005887; C:integral to plasma membrane; TAS:ProtInc.
 GO:0015174; F:basic amino acid transmembrane transporter activity; TAS:ProtInc.
 GO:0005289; F:high affinity arginine transmembrane transporter activity; IEA:Compara.
 GO:0015189; F:L-lysine transmembrane transporter activity; IEA:Compara.
 GO:0000064; F:L-ornithine transmembrane transporter activity; IEA:Compara.
 GO:0006520; P:cellular amino acid metabolic process; TAS:ProtInc.
 GO:0042116; P:macrophage activation; IEA:Compara.
 GO:0006809; P:nitric oxide biosynthetic process; IEA:Compara.
 GO:0002537; P:nitric oxide production involved in inflammatory response; IEA:Compara.
 GO:0050727; P:regulation of inflammatory response; IEA:Compara.
 GO:0043030; P:regulation of macrophage activation; IEA:Compara. 
Interpro
 IPR002293; AA/rel_permease1.
 IPR015606; Cat-AATrans.
 IPR004755; Cat_AA_permease. 
Pfam
  
SMART
  
PROSITE
  
PRINTS