CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-031537
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Translocon-associated protein subunit gamma 
Protein Synonyms/Alias
 cDNA FLJ52061, highly similar to Translocon-associated protein subunit gamma 
Gene Name
 SSR3 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
8MAPKGSSKQQSEEDLubiquitination[1, 2, 3, 4]
81AFAYKNVKFVLKHKVubiquitination[1, 5]
85KNVKFVLKHKVAQKRubiquitination[1]
98KREDAVSKEVTRKLSubiquitination[1, 3, 4]
103VSKEVTRKLSEADNRubiquitination[1]
Reference
 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094]
 [3] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [4] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661]
 [5] Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass.
 Povlsen LK, Beli P, Wagner SA, Poulsen SL, Sylvestersen KB, Poulsen JW, Nielsen ML, Bekker-Jensen S, Mailand N, Choudhary C.
 Nat Cell Biol. 2012 Oct;14(10):1089-98. [PMID: 23000965
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 198 AA 
Protein Sequence
MAPKGSSKQQ SEEDLLLQDF SRNLSAKSSA LFFGNAFIVS AIPIWLYWRI WHMDLIQSAV 60
LYSVMTLVST YLVAFAYKNV KFVLKHKVAQ KREDAVSKEV TRKLSEADNR KMSRKEKDER 120
FDSCLKYGHH KRGILWKKNE VADYEATTFS IFYNNTLFLV VVIVASFFIL KNFNPTVNYI 180
LSISASSGLI ALLSTGSK 198 
Gene Ontology
 GO:0030176; C:integral to endoplasmic reticulum membrane; IEA:InterPro.
 GO:0005784; C:Sec61 translocon complex; IEA:InterPro.
 GO:0006613; P:cotranslational protein targeting to membrane; IEA:InterPro. 
Interpro
 IPR009779; TRAP-gamma. 
Pfam
 PF07074; TRAP-gamma 
SMART
  
PROSITE
  
PRINTS