UniProt Accession

 EBP_MOUSE; P70245; Q9CSP4 

Genbank Protein ID

 X97755; AK012266; AK027977; BC004703; BC004620 

Genbank Nucleotide ID

 CAA66350.1; BAB28129.1; BAC25686.1; AAH04703.1; AAH04620.1 

Protein Name

 3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase 

Protein Synonyms/Alias

 Cholestenol Delta-isomerase; Delta(8)-Delta(7) sterol isomerase; D8-D7 sterol isomerase; Emopamil-binding protein 

Gene Name

 Ebp 

Gene Synonyms/Alias

 Msi 

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
221	AQSVLDSKVMKIKSK	ubiquitination	[1]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 

Functional Description

 Catalyzes the conversion of Delta(8)-sterols to their corresponding Delta(7)-isomers. 

Sequence Annotation

 MOD_RES 2 2 N-acetylthreonine.  

Keyword

 Acetylation; Cholesterol biosynthesis; Cholesterol metabolism; Complete proteome; Direct protein sequencing; Disease mutation; Endoplasmic reticulum; Isomerase; Lipid biosynthesis; Lipid metabolism; Membrane; Reference proteome; Steroid biosynthesis; Steroid metabolism; Sterol biosynthesis; Sterol metabolism; Transmembrane; Transmembrane helix. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 230 AA 

Protein Sequence

Gene Ontology

 GO:0005789; C:endoplasmic reticulum membrane; TAS:MGI.
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0000247; F:C-8 sterol isomerase activity; IDA:MGI.
 GO:0047750; F:cholestenol delta-isomerase activity; IEA:EC.
 GO:0006695; P:cholesterol biosynthetic process; IEA:UniProtKB-UniPathway.
 GO:0030097; P:hemopoiesis; IMP:MGI.
 GO:0016126; P:sterol biosynthetic process; IMP:MGI. 

Interpro

 IPR007905; EBP. 

Pfam

 PF05241; EBP 

SMART

  

PROSITE

  

PRINTS