UniProt Accession

 KAT8_MOUSE; Q9D1P2; Q3UIY0; Q8BJ69; Q8BJ76; Q8CI73 

Genbank Protein ID

 AK003264; AK018002; AK029350; AK146710; BC036284 

Genbank Nucleotide ID

 BAB22680.1; BAC25539.1; BAC26411.1; BAE27376.1; AAH36284.1 

Protein Name

 Histone acetyltransferase KAT8 

Protein Synonyms/Alias

 Lysine acetyltransferase 8; MOZ, YBF2/SAS3, SAS2 and TIP60 protein 1; MYST-1 

Gene Name

 Kat8 

Gene Synonyms/Alias

 Mof; Myst1 

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
154	DEINHVQKTYAEMDP	acetylation	[1]
168	PTTAALEKEHEAITK	acetylation	[1]
351	STVGSPEKPLSDLGK	acetylation	[1, 2, 3]

Reference

 [1] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441]
 [2] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377]
 [3] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
 Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
 Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337] 

Functional Description

 Histone acetyltransferase which may be involved in transcriptional activation. May influence the function of ATM. As part of the MSL complex it is involved in acetylation of nucleosomal histone H4 producing specifically H4K16ac. As part of the NSL complex it may be involved in acetylation of nucleosomal histone H4 on several lysine residues. That activity is less specific than the one of the MSL complex (By similarity). 

Sequence Annotation

 DOMAIN 69 123 Chromo.
 ZN_FING 208 230 C2HC-type.
 REGION 174 458 Sufficient for interaction with KANSL1
 REGION 324 330 Acetyl-CoA binding (By similarity).
 ACT_SITE 274 274 By similarity.
 ACT_SITE 316 316 Nucleophile (By similarity).
 BINDING 319 319 Acetyl-CoA (By similarity).
 BINDING 354 354 Acetyl-CoA (By similarity).
 MOD_RES 2 2 N-acetylalanine (By similarity).
 MOD_RES 37 37 Phosphoserine.
 MOD_RES 42 42 Phosphoserine.
 MOD_RES 113 113 N6-acetyllysine (By similarity).
 MOD_RES 274 274 N6-acetyllysine; by autocatalysis (By  

Keyword

 3D-structure; Acetylation; Activator; Acyltransferase; Alternative splicing; Chromatin regulator; Chromosome; Complete proteome; Metal-binding; Nucleus; Phosphoprotein; Reference proteome; Transcription; Transcription regulation; Transferase; Zinc; Zinc-finger. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 458 AA 

Protein Sequence

Gene Ontology

 GO:0000776; C:kinetochore; IDA:MGI.
 GO:0071339; C:MLL1 complex; ISS:UniProtKB.
 GO:0072487; C:MSL complex; ISS:UniProtKB.
 GO:0016407; F:acetyltransferase activity; IDA:UniProtKB.
 GO:0046972; F:histone acetyltransferase activity (H4-K16 specific); IEA:Compara.
 GO:0043995; F:histone acetyltransferase activity (H4-K5 specific); IEA:Compara.
 GO:0043996; F:histone acetyltransferase activity (H4-K8 specific); IEA:Compara.
 GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
 GO:0043984; P:histone H4-K16 acetylation; ISS:UniProtKB.
 GO:0043981; P:histone H4-K5 acetylation; ISS:UniProtKB.
 GO:0043982; P:histone H4-K8 acetylation; ISS:UniProtKB.
 GO:0030099; P:myeloid cell differentiation; IEA:Compara.
 GO:0045892; P:negative regulation of transcription, DNA-dependent; IEA:Compara.
 GO:0045893; P:positive regulation of transcription, DNA-dependent; ISS:UniProtKB.
 GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. 

Interpro

 IPR016181; Acyl_CoA_acyltransferase.
 IPR000953; Chromo_domain/shadow.
 IPR016197; Chromodomain-like.
 IPR002717; MOZ_SAS.
 IPR025995; Tudor-knot. 

Pfam

 PF01853; MOZ_SAS
 PF11717; Tudor-knot 

SMART

 SM00298; CHROMO 

PROSITE

 PS00598; CHROMO_1
 PS50013; CHROMO_2 

PRINTS