UniProt Accession

 NPRL2_HUMAN; Q8WTW4; A8K831; Q6FGS2; Q9Y249; Q9Y497 

Genbank Protein ID

 AF040707; AF040708; AK292196; CR542035; AC002481; CH471055; CH471055; BC021984; BC056861 

Genbank Nucleotide ID

 AAC62535.1; AAC62536.1; BAF84885.1; CAG46832.1; AAB67310.1; EAW65106.1; EAW65107.1; AAH21984.1; AAH56861.1 

Protein Name

 Nitrogen permease regulator 2-like protein 

Protein Synonyms/Alias

 NPR2-like protein; Gene 21 protein; G21 protein; Tumor suppressor candidate 4 

Gene Name

 NPRL2 

Gene Synonyms/Alias

 TUSC4 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
62	ITVTAMEKKLIGCPV	ubiquitination	[1]
63	TVTAMEKKLIGCPVC	ubiquitination	[2]
94	FVCDAQAKTCALEPI	ubiquitination	[2]
103	CALEPIVKKLAGYLT	ubiquitination	[3]
104	ALEPIVKKLAGYLTT	ubiquitination	[2]
158	ESNTIHLKVIEQRPD	ubiquitination	[2]
179	YDVPVFTKDKEDFFN	ubiquitination	[1]
258	VQDLVDDKSLQEACL	ubiquitination	[3]
312	LQHVDERKLIQFGLM	ubiquitination	[2]
320	LIQFGLMKNLIRRLQ	ubiquitination	[2, 3]
328	NLIRRLQKYPVRVTR	ubiquitination	[2]
357	SYDEICCKTGMSYHE	ubiquitination	[2, 3]

Reference

 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [3] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094] 

Functional Description

 Suppresses Src-dependent tyrosine phosphorylation and activation of PDPK1 and its downstream signaling. Down-regulates PDPK1 kinase activity by interfering with tyrosine phosphorylation at the Tyr-9 Tyr-373 and Tyr-376 residues. May act as a tumor suppressor. Suppresses cell growth and enhanced sensitivity to various anticancer drugs. 

Sequence Annotation

 REGION 1 133 Interaction with PDPK1.  

Keyword

 Alternative splicing; Complete proteome; Reference proteome; Tumor suppressor. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 380 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IDA:HPA.
 GO:0004672; F:protein kinase activity; IDA:UniProtKB.
 GO:0033673; P:negative regulation of kinase activity; IDA:UniProtKB. 

Interpro

 IPR009348; NPR2. 

Pfam

 PF06218; NPR2 

SMART

  

PROSITE

  

PRINTS