UniProt Accession

 AT7L3_MOUSE; A2AWT3; A2AWT2; A2AWT4; Q8C1T7 

Genbank Protein ID

 AL954730; AL954730; AL954730; CH466558; AK090368 

Genbank Nucleotide ID

 CAM25078.1; CAM25079.1; CAM25080.1; EDL34107.1; BAC41186.1 

Protein Name

 Ataxin-7-like protein 3 

Protein Synonyms/Alias

 SAGA-associated factor 11 homolog 

Gene Name

 Atxn7l3 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
2	******MKMEEMSLS	acetylation	[1]

Reference

 [1] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441] 

Functional Description

 Component of the transcription regulatory histone acetylation (HAT) complex SAGA, a multiprotein complex that activates transcription by remodeling chromatin and mediating histone acetylation and deubiquitination. Within the SAGA complex, participates in a subcomplex that specifically deubiquitinates both histones H2A and H2B. The SAGA complex is recruited to specific gene promoters by activators such as MYC, where it is required for transcription. Required for nuclear receptor-mediated transactivation. Within the complex, it is required to recruit USP22 and ENY2 into the SAGA complex (By similarity). 

Sequence Annotation

 DOMAIN 196 263 SCA7.
 ZN_FING 84 105 SGF11-type.
 MOD_RES 129 129 Phosphoserine (By similarity).
 MOD_RES 131 131 Phosphoserine (By similarity).
 MOD_RES 278 278 Phosphoserine (By similarity).
 MOD_RES 281 281 Phosphoserine (By similarity).
 MOD_RES 326 326 Phosphoserine (By similarity).  

Keyword

 Activator; Alternative splicing; Chromatin regulator; Complete proteome; Metal-binding; Nucleus; Phosphoprotein; Reference proteome; Transcription; Transcription regulation; Zinc; Zinc-finger. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 347 AA 

Protein Sequence

Gene Ontology

 GO:0000124; C:SAGA complex; ISS:UniProtKB.
 GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
 GO:0003713; F:transcription coactivator activity; ISS:UniProtKB.
 GO:0016568; P:chromatin modification; IEA:UniProtKB-KW.
 GO:0045893; P:positive regulation of transcription, DNA-dependent; ISS:UniProtKB.
 GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. 

Interpro

 IPR013246; SAGA_su_Sgf11.
 IPR013243; SCA7_dom. 

Pfam

 PF08313; SCA7
 PF08209; Sgf11 

SMART

  

PROSITE

 PS51505; SCA7 

PRINTS