CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-003759
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 RANBP2-like and GRIP domain-containing protein 1 
Protein Synonyms/Alias
 Ran-binding protein 2-like 6; RanBP2-like 6; RanBP2L6 
Gene Name
 RGPD1 
Gene Synonyms/Alias
 RANBP2L6; RGP1 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
126SPAIYKLKEHLLDCEubiquitination[1]
755SEGGPLYKNGSLRNAubiquitination[1]
810KMICQEVKAITKLNSubiquitination[1]
919SEPGNQEKKSEKPLEubiquitination[1]
920EPGNQEKKSEKPLENubiquitination[1]
923NQEKKSEKPLENDTGubiquitination[1]
986GFSGAGEKLFSSQCGubiquitination[1]
994LFSSQCGKMANKANTubiquitination[1]
1050VLYSQGVKLFRFDAEubiquitination[2]
1062DAEISQWKERGLGNLubiquitination[1]
1073LGNLKILKNEVNGKPubiquitination[1]
1079LKNEVNGKPRMLMRRubiquitination[1]
1127DFSDGDAKLERLAAQubiquitination[1]
1136ERLAAQFKTPELAEEubiquitination[1]
1145PELAEEFKQKFEECQubiquitination[1]
1147LAEEFKQKFEECQRLubiquitination[1]
1603QSSDSKVKNLSASFPubiquitination[1]
1648QKLSSTTKSADQLNGubiquitination[1]
1731LSPEEKGKLAAVAQGubiquitination[1]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661] 
Functional Description
  
Sequence Annotation
 REPEAT 51 84 TPR 1.
 REPEAT 575 608 TPR 2.
 REPEAT 639 672 TPR 3.
 DOMAIN 1021 1157 RanBD1 1.
 DOMAIN 1318 1454 RanBD1 2.
 DOMAIN 1685 1735 GRIP.
 MOD_RES 14 14 Phosphothreonine (By similarity).  
Keyword
 Complete proteome; Phosphoprotein; Reference proteome; Repeat; TPR repeat. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1748 AA 
Protein Sequence
MNVMGFNTDR LAWTRNKLRG FYFAKLYYEA KEYDLAKKYV CTYLSVQERD PRAHRFLGLL 60
YELEENTEKA VECYRRSLEL NPPQKDLVLK IAELLCKNDV TDGRAKYWVE RAAKLFPGSP 120
AIYKLKEHLL DCEGEDGWNK LFDWIQSELY VRPDDVHMNI RLVELYRSNK RLKDAVARCH 180
EAERNIALRS SLEWNSCVVQ TLKEYLESLQ CLESDKSDWR ATNTDLLLAY ANLMLLTLST 240
RDVQESRELL ESFDSALQSA KSSLGGNDEL SATFLEMKGH FYMHAGSLLL KMGQHGNNVQ 300
WQALSELAAL CYVIAFQVPR PKIKLIKGEA GQNLLEMMAC DRLSQSGHML LNLSRGKQDF 360
LKEVVETFAN KSGQSVLYNA LFSSQSSKDT SFLGSDDIGN IDVQEPELED LARYDVGAIQ 420
AHNGSLQHLT WLGLQWNSLP ALPGIRKWLK QLFHHLPQET SRLETNAPES ICILDLEVFL 480
LGVVYTSHLQ LKEKCNSHHS SYQPLCLPLP VCKRLCTERQ KSWWDAVCTL IHRKAVPGNS 540
AELRLVVQHE INTLRAQEKH GLQPALLVHW AKCLQKMGRG LNSSYDQQEY IGRSVHYWKK 600
VLPLLKIIKK NSIPEPIDPL FKHFHSVDIQ ASEIVEYEED AHITFAILDA VHGNIEDAVT 660
AFESIKSVVS YWNLALIFHR KAEDIENDAV FPEEQEECKN YLRKTRDYLI KIIDDSDSNL 720
SVVKKLPVPL ESVKEMLKSV MQELEDYSEG GPLYKNGSLR NADSEIKHST PSPTKYSLSP 780
SKSYKYSPKT PPRWAEDQNS LRKMICQEVK AITKLNSSKS ASRHRWPTEN YGPDSVPDGY 840
QGSQTFHGAP LTVATTGPSV YYSQSPAYNS QYLLRPAANV TPTKGSSNTE FKSTKEGFSI 900
AVSADGFKFG ISEPGNQEKK SEKPLENDTG FQAQDISGQK NGRGVIFGQT SSTFTFADVA 960
KSTSGEGFQF GKKDPNFKGF SGAGEKLFSS QCGKMANKAN TSGDFEKDDD ACKTEDSDDI 1020
HFEPVVQMPE KVELVTGEEG EKVLYSQGVK LFRFDAEISQ WKERGLGNLK ILKNEVNGKP 1080
RMLMRRDQVL KVCANHWITT TMNLKPLSGS DRAWMWLASD FSDGDAKLER LAAQFKTPEL 1140
AEEFKQKFEE CQRLLLDIPL QTPHKLVDTG RAAKLIQRAE EMKSGLKDFK TFLTNDQTKV 1200
TEEENKGSGT GAAGASDTTI KPNPENTGPT LEWDNYDLRE DALDDNVSSS SVHDSPLASS 1260
PVRKNIFRFD ESTTGFNFSF KSALSLSKSP AKLNQSGTSV GTDEESDVTQ EEERDGQYFE 1320
PVVPLPDLVE VSSGEENEQV VFSHRAELYR YDKDVGQWKE RGIGDIKILQ NYDNKQVRIV 1380
MRRDQVLKLC ANHRITPDMS LQNMKGTERV WVWTACDFAD GERKVEHLAV RFKLQDVADS 1440
FKKIFDEAKT AQEKDSLITP HVSRSSTPRE SPCGKIAVAV LEETTRERTD VIQGDDVADA 1500
ASEVEVSSTS ETTTKAVVSP PKFVFGSESV KRIFSSEKSN PFAFGNSSAT GSLFGFSFNA 1560
PLKSNDSETS SVAQSGSESK VEPKKCELSK NSDIEQSSDS KVKNLSASFP MEESSINYTF 1620
KTPEKEPPLW HAEFTKEELV QKLSSTTKSA DQLNGLLRET EATSAVLMEQ IKLLKSEIRR 1680
LERNQEESAA NVEHLKNVLL QFIFLKPGSE RESLLPVINT MLQLSPEEKG KLAAVAQGLQ 1740
ETSIPKKK 1748 
Gene Ontology
 GO:0000042; P:protein targeting to Golgi; IEA:InterPro. 
Interpro
 IPR000237; GRIP.
 IPR011993; PH_like_dom.
 IPR000156; Ran_bind_dom.
 IPR001440; TPR-1.
 IPR013026; TPR-contain_dom.
 IPR011990; TPR-like_helical.
 IPR019734; TPR_repeat. 
Pfam
 PF01465; GRIP
 PF00638; Ran_BP1
 PF00515; TPR_1 
SMART
 SM00755; Grip
 SM00160; RanBD 
PROSITE
 PS50913; GRIP
 PS50196; RANBD1
 PS50005; TPR
 PS50293; TPR_REGION 
PRINTS