| Tag | Content |
|---|
| CPLM ID | CPLM-015253 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Helicase-like transcription factor |
Protein Synonyms/Alias | P113; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 3; Sucrose nonfermenting protein 2-like 3; TNF-response element-binding protein |
Gene Name | Hltf |
Gene Synonyms/Alias | Smarca3; Snf2l3; Zbu1 |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 982 | AAGAFGTKKTDANDM | ubiquitination | [1] |
|
Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | Has both helicase and E3 ubiquitin ligase activities. Possesses intrinsic ATP-dependent nucleosome-remodeling activity. This activity may be required for transcriptional activation or repression of specific target promoters (By similarity). These may include the SERPINE1, to which this protein can bind directly. Plays a role in error-free postreplication repair (PRR) of damaged DNA and maintains genomic stability through acting as a ubiquitin ligase for 'Lys-63'-linked polyubiquitination of chromatin-bound PCNA (By similarity). |
Sequence Annotation | DOMAIN 433 600 Helicase ATP-binding.
DOMAIN 831 990 Helicase C-terminal.
NP_BIND 294 301 ATP (By similarity).
ZN_FING 754 795 RING-type.
REGION 38 287 DNA binding (By similarity).
REGION 919 1003 Interaction with SP1 and SP3 (By
MOTIF 551 554 DEGH box.
MOD_RES 195 195 Phosphotyrosine; by JAK2.
MOD_RES 394 394 Phosphoserine (By similarity).
MOD_RES 395 395 Phosphoserine (By similarity).
MOD_RES 397 397 Phosphoserine (By similarity).
MOD_RES 629 629 Phosphoserine.
MOD_RES 730 730 Phosphothreonine (By similarity). |
Keyword | Activator; ATP-binding; Chromatin regulator; Complete proteome; Cytoplasm; DNA-binding; Helicase; Hydrolase; Ligase; Metal-binding; Multifunctional enzyme; Nucleotide-binding; Nucleus; Phosphoprotein; Reference proteome; Transcription; Ubl conjugation pathway; Zinc; Zinc-finger. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 1003 AA |
Protein Sequence | MSYTFTRGPV WKYSQSVQYG SHENIPRLSY STFLPHFEFQ DIIPPDDFLT SDEEQDLVLF 60
GTMRGQVVGL RYYTGVVNNN EMVALQREPN NPYDKNAIKV NNVNGNQVGH IKREIAAAVA 120
YIMDNKLAQV EGVVPFGASN TFTMPLYMTF WGKEENRNVV LEQLKKHGFK LGPTPKTLGS 180
SLENAWGSGR AGPSYSRPAH VAVQMTTDQL KTEFDKLFED LKEDDRTVEM EPAEAIETPL 240
LPHQKQALAW MIARENSKEL PPFWEQRNDL YYNTITNFSV KERPENVHGG ILADDMGLGK 300
TLTAIAVILT NFDDGRPLLS KRGKKNHPGK EYKDETIKRR GSNMDKKEDG HSESSTCGEE 360
PSISGTPEKS SCTLSQLSSV CPKRRKISVQ YIESSDSEEI ETSELPQKMK GKLKNVQLNT 420
KSRVKGSSKV KEDSKFALTF FASATQRKML KKGMSMMECS EACDTGERTR ATLIICPLSV 480
LSNWIDQFGQ HVKSEVHLNF YVYYGPDRIR DSAWLSKQDI ILTTYNILTH DYGTKDDSPL 540
HSIKWLRVIL DEGHAIRNPN AQQTKAVLEL EAERRWVLTG TPIQNSLKDL WSLLSFLKLK 600
PFIDREWWYR IIQRPVTTGD EGGLRRLQSL IKNITLRRTK TSKIKGKPVL ELPERKVFIQ 660
HITLSEEERK IYQSVKNEGK AAIGRYFTEG TVLAHYADVL GLLLRLRQIC CHTHLLTNGM 720
SSSGPSRSDT PEELRKMLIE KMKIILSSGS DEECAICLDS LTFPVITHCA HVFCKPCICQ 780
VIHSEQPHAK CPLCRNEIHG DNLLECPPEE LACDSDKESS MEWKSSSKIN ALMHALIELR 840
TKDPNIKSLV VSQFTTFLSL IETPLKASGF VFTRLDGSMA QKKRVESIQR FQNTEAGSPT 900
IMLLSLKAGG VGLNLCAASR VFLMDPAWNP AAEDQCFDRC HRLGQKQEVI ITKFIVKDSV 960
EENMLKIQNT KRDLAAGAFG TKKTDANDMK QAKINEIRTL IDL 1003 |
Gene Ontology | GO:0005634; C:nucleus; IEA:UniProtKB-SubCell. GO:0005524; F:ATP binding; IEA:UniProtKB-KW. GO:0016887; F:ATPase activity; IDA:MGI. GO:0003677; F:DNA binding; IEA:UniProtKB-KW. GO:0004386; F:helicase activity; IEA:UniProtKB-KW. GO:0016874; F:ligase activity; IEA:UniProtKB-KW. GO:0008270; F:zinc ion binding; IEA:InterPro. GO:0016568; P:chromatin modification; IEA:UniProtKB-KW. GO:0016567; P:protein ubiquitination; IEA:UniProtKB-UniPathway. GO:0006357; P:regulation of transcription from RNA polymerase II promoter; IDA:MGI. GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. |
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