| Tag | Content |
|---|
| CPLM ID | CPLM-014598 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Interferon-induced protein with tetratricopeptide repeats 1 |
Protein Synonyms/Alias | IFIT-1; Glucocorticoid-attenuated response gene 16 protein; GARG-16; Interferon-induced 56 kDa protein; IFI-56K; P56 |
Gene Name | Ifit1 |
Gene Synonyms/Alias | Garg16; Ifi56; Isg56 |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 287 | YQKGLCYKQQISQLR | ubiquitination | [1] |
|
Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | Interferon-induced antiviral RNA-binding protein that specifically binds single-stranded RNA bearing a 5'-triphosphate group (PPP-RNA), thereby acting as a sensor of viral single- stranded RNAs and inhibiting expression of viral messenger RNAs. Single-stranded PPP-RNAs, which lack 2'-O-methylation of the 5' cap and bear a 5'-triphosphate group instead, are specific from viruses, providing a molecular signature to distinguish between self and non-self mRNAs by the host during viral infection. Directly binds PPP-RNA in a non-sequence-specific manner. Viruses evolved several ways to evade this restriction system such as encoding their own 2'-O-methylase for their mRNAs or by stealing host cap containing the 2'-O-methylation (cap snatching mechanism). |
Sequence Annotation | REPEAT 52 85 TPR 1.
REPEAT 92 126 TPR 2.
REPEAT 136 171 TPR 3.
REPEAT 174 207 TPR 4.
REPEAT 209 241 TPR 5.
REPEAT 242 275 TPR 6.
REPEAT 294 328 TPR 7.
REPEAT 329 362 TPR 8.
REPEAT 367 401 TPR 9.
REPEAT 426 459 TPR 10.
REGION 247 253 Interaction with the 5'-triphosphate |
Keyword | Antiviral defense; Complete proteome; Cytoplasm; Immunity; Innate immunity; Phosphoprotein; Reference proteome; Repeat; RNA-binding; TPR repeat. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 463 AA |
Protein Sequence | MGENADGDQV MENLLQLRCH FTWKLLFENN DIPDLEVRIS EQVQFLDIKN PLGMHNLLAY 60
VRHLKGQQDE ALQSLKEAEA LIQSEQLSKR SLATWGNCAW LHYHRGSLAE AQIYLDKVEK 120
VCKEFSSPFR YRLECAEMDC EEGWALLKCG GGNYKQAMAC FAKALKVEPE NPEYNTGYAV 180
VAYRQDLDDN FISLEPLRKA VRLNPEDPYL KVLLALKLQD LGEHVEAEAH IEEALSSTSC 240
QSYVIRYAAK YFRRKHRVDK ALHLLNRALQ ASPSSGYLHY QKGLCYKQQI SQLRTSRNRQ 300
PRRQDNVQEL AQQAIHEFQE TLKLRPTFEM AYVCMAEVQA EIHQYEEAER NFQKALNNKT 360
LVAHIEQDIH LRYGRFLQFH KQSEDKAITL YLKGLKVEEK SFAWRKLLTA LEKVAERRVC 420
QNVHLVESTS LLGLVYKLKG QEKNALFYYE KALRLTGEMN PAF 463 |
Gene Ontology | GO:0005737; C:cytoplasm; IDA:UniProtKB. GO:0003723; F:RNA binding; ISS:UniProtKB. GO:0071360; P:cellular response to exogenous dsRNA; IEA:InterPro. GO:0035457; P:cellular response to interferon-alpha; IDA:MGI. GO:0035458; P:cellular response to interferon-beta; IDA:MGI. GO:0071357; P:cellular response to type I interferon; IEA:InterPro. GO:0051607; P:defense response to virus; IEA:UniProtKB-KW. GO:0050688; P:regulation of defense response to virus; IEA:InterPro. GO:0009615; P:response to virus; IMP:UniProtKB. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |