CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-019079
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Axin interactor, dorsalization-associated protein 
Protein Synonyms/Alias
 Axin interaction partner and dorsalization antagonist 
Gene Name
 AIDA 
Gene Synonyms/Alias
 C1orf80 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
235KHVEKLTKGAAIFFEacetylation[1]
Reference
 [1] Regulation of cellular metabolism by protein lysine acetylation.
 Zhao S, Xu W, Jiang W, Yu W, Lin Y, Zhang T, Yao J, Zhou L, Zeng Y, Li H, Li Y, Shi J, An W, Hancock SM, He F, Qin L, Chin J, Yang P, Chen X, Lei Q, Xiong Y, Guan KL.
 Science. 2010 Feb 19;327(5968):1000-4. [PMID: 20167786] 
Functional Description
 Acts as a ventralizing factor during embryogenesis. Inhibits axin-mediated JNK activation by binding axin and disrupting axin homodimerization. This in turn antagonizes a Wnt/beta-catenin-independent dorsalization pathway activated by AXIN/JNK-signaling (By similarity). 
Sequence Annotation
 REGION 154 221 Axin-binding (By similarity).
 MOD_RES 144 144 Phosphoserine.  
Keyword
 Alternative splicing; Coiled coil; Complete proteome; Developmental protein; Phosphoprotein; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 306 AA 
Protein Sequence
MSEVTRSLLQ RWGASFRRGA DFDSWGQLVE AIDEYQILAR HLQKEAQAQH NNSEFTEEQK 60
KTIGKIATCL ELRSAALQST QSQEEFKLED LKKLEPILKN ILTYNKEFPF DVQPVPLRRI 120
LAPGEEENLE FEEDEEEGGA GAGSPDSFPA RVPGTLLPRL PSEPGMTLLT IRIEKIGLKD 180
AGQCIDPYIT VSVKDLNGID LTPVQDTPVA SRKEDTYVHF NVDIELQKHV EKLTKGAAIF 240
FEFKHYKPKK RFTSTKCFAF MEMDEIKPGP IVIELYKKPT DFKRKKLQLL TKKPLYLHLH 300
QTLHKE 306 
Gene Ontology
 GO:0009953; P:dorsal/ventral pattern formation; ISS:UniProtKB.
 GO:0046329; P:negative regulation of JNK cascade; ISS:UniProtKB.
 GO:0043508; P:negative regulation of JUN kinase activity; IDA:MGI.
 GO:0043496; P:regulation of protein homodimerization activity; ISS:UniProtKB. 
Interpro
 IPR015006; AIDA.
 IPR025939; Aida_C.
 IPR023421; AIDA_N. 
Pfam
 PF08910; Aida-C2
 PF14186; Aida_C2 
SMART
  
PROSITE
  
PRINTS