CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-012427
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Sarcolemmal membrane-associated protein 
Protein Synonyms/Alias
 Sarcolemmal-associated protein 
Gene Name
 SLMAP 
Gene Synonyms/Alias
 KIAA1601; SLAP; UNQ1847/PRO3577 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
29VYLDEPIKIGRSVARacetylation[1]
229NQLQACSKNQTEDSLubiquitination[2]
238QTEDSLRKELIALQEubiquitination[2]
Reference
 [1] Lysine acetylation targets protein complexes and co-regulates major cellular functions.
 Choudhary C, Kumar C, Gnad F, Nielsen ML, Rehman M, Walther TC, Olsen JV, Mann M.
 Science. 2009 Aug 14;325(5942):834-40. [PMID: 19608861]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 
Functional Description
 May play a role during myoblast fusion (By similarity). 
Sequence Annotation
 DOMAIN 28 85 FHA.
 REGION 1 163 Necessary for targeting to centrosomes
 MOD_RES 452 452 Phosphoserine.  
Keyword
 Alternative splicing; Cell membrane; Coiled coil; Complete proteome; Cytoplasm; Cytoskeleton; Membrane; Phosphoprotein; Reference proteome; Transmembrane; Transmembrane helix. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 828 AA 
Protein Sequence
MPSALAIFTC RPNSHPFQER HVYLDEPIKI GRSVARCRPA QNNATFDCKV LSRNHALVWF 60
DHKTGKFYLQ DTKSSNGTFI NSQRLSRGSE ESPPCEILSG DIIQFGVDVT ENTRKVTHGC 120
IVSTIKLFLP DGMEARLRSD VIHAPLPSPV DKVAANTPSM YSQELFQLSQ YLQEALHREQ 180
MLEQKLATLQ RLLAITQEAS DTSWQALIDE DRLLSRLEVM GNQLQACSKN QTEDSLRKEL 240
IALQEDKHNY ETTAKESLRR VLQEKIEVVR KLSEVERSLS NTEDECTHLK EMNERTQEEL 300
RELANKYNGA VNEIKDLSDK LKVAEGKQEE IQQKGQAEKK ELQHKIDEME EKEQELQAKI 360
EALQADNDFT NERLTALQVR LEHLQEKTLK ECSSLEHLLS KSGGDCTFIH QFIECQKKLI 420
VEGHLTKAVE ETKLSKENQT RAKESDFSDT LSPSKEKSSD DTTDAQMDEQ DLNEPLAKVS 480
LLKDDLQGAQ SEIEAKQEIQ HLRKELIEAQ ELARTSKQKC FELQALLEEE RKAYRNQVEE 540
STKQIQVLQA QLQRLHIDTE NLREEKDSEI TSTRDELLSA RDEILLLHQA AAKVASERDT 600
DIASLQEELK KVRAELERWR KAASEYEKEI TSLQNSFQLR CQQCEDQQRE EATRLQGELE 660
KLRKEWNALE TECHSLKREN VLLSSELQRQ EKELHNSQKQ SLELTSDLSI LQMSRKELEN 720
QVGSLKEQHL RDSADLKTLL SKAENQAKDV QKEYEKTQTV LSELKLKFEM TEQEKQSITD 780
ELKQCKNNLK LLREKGNNKP WPWMPMLAAL VAVTAIVLYV PGLARASP 828 
Gene Ontology
 GO:0005887; C:integral to plasma membrane; TAS:ProtInc.
 GO:0005815; C:microtubule organizing center; IEA:UniProtKB-SubCell.
 GO:0042383; C:sarcolemma; IEA:UniProtKB-SubCell.
 GO:0005790; C:smooth endoplasmic reticulum; TAS:ProtInc.
 GO:0006936; P:muscle contraction; TAS:ProtInc. 
Interpro
 IPR000253; FHA_dom.
 IPR002777; PFD_beta-like.
 IPR008984; SMAD_FHA_domain. 
Pfam
 PF00498; FHA
 PF01920; Prefoldin_2 
SMART
 SM00240; FHA 
PROSITE
 PS50006; FHA_DOMAIN 
PRINTS