CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-038751
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Potassium-transporting ATPase alpha chain 1 
Protein Synonyms/Alias
  
Gene Name
 Atp4a 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
3*****MGKAENYELYacetylation[1]
518SRHLLVMKGAPERVLacetylation[2]
518SRHLLVMKGAPERVLubiquitination[3]
Reference
 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405]
 [2] Quantitative assessment of the impact of the gut microbiota on lysine epsilon-acetylation of host proteins using gnotobiotic mice.
 Simon GM, Cheng J, Gordon JI.
 Proc Natl Acad Sci U S A. 2012 Jul 10;109(28):11133-8. [PMID: 22733758]
 [3] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
  
Sequence Annotation
  
Keyword
 ATP-binding; Complete proteome; Hydrolase; Membrane; Nucleotide-binding; Phosphoprotein; Reference proteome; Transmembrane; Transmembrane helix. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1034 AA 
Protein Sequence
MGKAENYELY SVELGSGPGG DMTAKMSKKK AGGGGGKKKE KLENMKKEME INDHQLSVSE 60
LEQKYQTSAT KGLKASLAAE LLLRDGPNAL RPPRGTPEYV KFARQLAGGL QCLMWVAAAI 120
CLIAFAIQAS EGDLTTDDNL YLAVALIAVV VVTGCFGYYQ EFKSTNIIAS FKNLVPQQAT 180
VIRDGDKFQI NADQLVVGDL VEMKGGDRVP ADIRILSAQG CKVDNSSLTG ESEPQTRSPE 240
CTHESPLETR NIAFFSTMCL EGTAQGLVVS TGDRTIIGRI ASLASGVENE KTPIAIEIEH 300
FVDIIAGLAI LFGATFFVVA MCIGYTFLRA MVFFMAIVVA YVPEGLLATV TVCLSLTAKR 360
LASKNCVVKN LEAVETLGST SVICSDKTGT LTQNRMTVSH LWFDNHIHTA DTTEDQSGQT 420
FDQSSETWRA LCRVLTLCNR AAFKSGQDAV PVPKRIVIGD ASETALLKFS ELTLGNAMGY 480
RDRFPKVCEI PFNSINKFQL SIHTLEDPRD SRHLLVMKGA PERVLERCSS ILIKGQELPL 540
DEQWREAFQT AYLSLGGLGE RVLGFCQLYL NEKDYPPGYA FDVEAMNFPS SGLCFAGLVS 600
MIDPPRATVP DAVLKCRTAG IRVIMVTGDH PITAKAIAAS VGIISEGSET VEDIAARLRM 660
PVDQVNRKDA RACVINGMQL KDMDPSELVE ALRTHPEMVF ARTSPQQKLV IVESCQRLGA 720
IVAVTGDGVN DSPALKKADI GVAMGIAGSD AAKNAADMIL LDDNFASIVT GVEQGRLIFD 780
NLKKSIAYTL TKNIPELTPY LIYITVSVPL PLGCITILFI ELCTDIFPSV SLAYEKAESD 840
IMHLRPRNPK RDRLVNEPLA AYSYFQIGAI QSFAGFADYF TAMAQEGWFP LLCVGLRPQW 900
EDHHLQDLQD SYGQEWTFGQ RLYQQYTCYT VFFISIEMCQ IADVLIRKTR RLSVFQQGFF 960
RNKILVIAIV FQVCIGCFLC YCPGMPNIFN FMPIRFQWWL VPMPFGLLIF VYDEIRKLGV 1020
RCCPGSWWDQ ELYY 1034 
Gene Ontology
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0005886; C:plasma membrane; IDA:MGI.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0008900; F:hydrogen:potassium-exchanging ATPase activity; IDA:MGI.
 GO:0000287; F:magnesium ion binding; IEA:InterPro.
 GO:0006754; P:ATP biosynthetic process; IEA:InterPro.
 GO:0015991; P:ATP hydrolysis coupled proton transport; IEA:InterPro.
 GO:0045851; P:pH reduction; IDA:MGI.
 GO:0010155; P:regulation of proton transport; IDA:MGI.
 GO:0042493; P:response to drug; IDA:MGI. 
Interpro
 IPR006068; ATPase_P-typ_cation-transptr_C.
 IPR004014; ATPase_P-typ_cation-transptr_N.
 IPR023299; ATPase_P-typ_cyto_domN.
 IPR015127; ATPase_P-typ_H/K-transp_N.
 IPR005775; ATPase_P-typ_Na/K_IIC.
 IPR018303; ATPase_P-typ_P_site.
 IPR023298; ATPase_P-typ_TM_dom.
 IPR008250; ATPase_P-typ_transduc_dom_A.
 IPR001757; Cation_transp_P_typ_ATPase.
 IPR023214; HAD-like_dom. 
Pfam
 PF00689; Cation_ATPase_C
 PF00690; Cation_ATPase_N
 PF00122; E1-E2_ATPase
 PF09040; H-K_ATPase_N
 PF00702; Hydrolase 
SMART
 SM00831; Cation_ATPase_N 
PROSITE
 PS00154; ATPASE_E1_E2 
PRINTS
 PR00119; CATATPASE.