CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-042240
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Succinyl-CoA:3-ketoacid-coenzyme A transferase 
Protein Synonyms/Alias
  
Gene Name
 LOC100733415 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Cavia porcellus (Guinea pig) 
NCBI Taxa ID
 10141 
Lysine Modification
Position
Peptide
Type
References
296DGKAKSAKPADNVREacetylation[1]
421MIPGKMVKGMGGAMDacetylation[1]
455NAHKIMEKCTLPLTGacetylation[1]
473VNRIITEKAVFDVDKacetylation[1]
480KAVFDVDKKKGLTLIacetylation[1]
Reference
 [1] The cardiac acetyl-lysine proteome.
 Foster DB, Liu T, Rucker J, O'Meally RN, Devine LR, Cole RN, O'Rourke B.
 PLoS One. 2013;8(7):e67513. [PMID: 23844019] 
Functional Description
 Key enzyme for ketone body catabolism. Transfers the CoA moiety from succinate to acetoacetate. Formation of the enzyme-CoA intermediate proceeds via an unstable anhydride species formed between the carboxylate groups of the enzyme and substrate (By similarity). 
Sequence Annotation
  
Keyword
 Complete proteome; Mitochondrion; Reference proteome; Transferase. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 520 AA 
Protein Sequence
MAAFKLLSSG LRLGASARSS GAAWSKGCVC YFSTSTHHHT KFYTDAVEAV KDIPDGATIL 60
VGGFGLCGIP ENLIGALLQT GVKGLTAVSN NAGVDNFGLG LLLRSKQIKR MVSSYVGENA 120
EFERQFLSGE LEVELTPQGT LAERIRAGGA GVPAFYTSTG YGTLVQEGGA PIKYNKDGSI 180
AIASKPREVR EFNGQQFILE EAITGDFALV KAWKADQAGN VIFRKSARNF NLPMCKAAET 240
TVVEVEEIVD IGSFAPEDIH IPKIYVHRLI KGEKYEKRIE RLSIRKKDDG KAKSAKPADN 300
VRERIIRRAA LEFEDGMYAN LGIGIPLLAS NFISPNMTVH LQSENGVLGL GPYPLEHEAD 360
ADLINAGKET VTVLPGASFF SSDESFAMIR GGHVDLTMLG AMQVSKYGDL ANWMIPGKMV 420
KGMGGAMDLV SSAKTKVVVT MEHSAKGNAH KIMEKCTLPL TGKQCVNRII TEKAVFDVDK 480
KKGLTLIELW EGLTVDDIQK STGCDFAVSV SVSETSLLGC 520 
Gene Ontology
 GO:0005739; C:mitochondrion; IEA:UniProtKB-KW.
 GO:0008260; F:3-oxoacid CoA-transferase activity; IEA:EC.
 GO:0046952; P:ketone body catabolic process; IEA:Compara.
 GO:0042182; P:ketone catabolic process; IEA:Compara. 
Interpro
 IPR012792; 3-oxoacid_CoA-transf_A.
 IPR012791; 3-oxoacid_CoA-transf_B.
 IPR014388; 3-oxoacid_CoA-transferase.
 IPR004165; CoA_trans_fam_I.
 IPR004164; CoA_transf_AS.
 IPR004163; CoA_transf_BS. 
Pfam
 PF01144; CoA_trans 
SMART
 SM00882; CoA_trans 
PROSITE
 PS01273; COA_TRANSF_1
 PS01274; COA_TRANSF_2 
PRINTS