| Tag | Content |
|---|
| CPLM ID | CPLM-012398 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Metabotropic glutamate receptor 3 |
Protein Synonyms/Alias | mGluR3 |
Gene Name | GRM3 |
Gene Synonyms/Alias | GPRC1C; MGLUR3 |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 266 | VIRELLQKPNARVVV | ubiquitination | [1] |
|
Reference | [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments. Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA. Mol Cell Proteomics. 2013 Mar;12(3):825-31. [ PMID: 23266961] |
Functional Description | Receptor for glutamate. The activity of this receptor is mediated by a G-protein that inhibits adenylate cyclase activity. |
Sequence Annotation | CARBOHYD 209 209 N-linked (GlcNAc...) (Potential).
CARBOHYD 292 292 N-linked (GlcNAc...) (Potential).
CARBOHYD 414 414 N-linked (GlcNAc...) (Potential).
CARBOHYD 439 439 N-linked (GlcNAc...) (Potential).
DISULFID 57 99 By similarity.
DISULFID 240 527 By similarity.
DISULFID 361 373 By similarity.
DISULFID 412 419 By similarity.
DISULFID 509 528 By similarity.
DISULFID 513 531 By similarity.
DISULFID 534 546 By similarity.
DISULFID 549 562 By similarity. |
Keyword | 3D-structure; Cell membrane; Complete proteome; Disulfide bond; G-protein coupled receptor; Glycoprotein; Membrane; Polymorphism; Receptor; Reference proteome; Signal; Transducer; Transmembrane; Transmembrane helix. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 879 AA |
Protein Sequence | MKMLTRLQVL TLALFSKGFL LSLGDHNFLR REIKIEGDLV LGGLFPINEK GTGTEECGRI 60
NEDRGIQRLE AMLFAIDEIN KDDYLLPGVK LGVHILDTCS RDTYALEQSL EFVRASLTKV 120
DEAEYMCPDG SYAIQENIPL LIAGVIGGSY SSVSIQVANL LRLFQIPQIS YASTSAKLSD 180
KSRYDYFART VPPDFYQAKA MAEILRFFNW TYVSTVASEG DYGETGIEAF EQEARLRNIC 240
IATAEKVGRS NIRKSYDSVI RELLQKPNAR VVVLFMRSDD SRELIAAASR ANASFTWVAS 300
DGWGAQESII KGSEHVAYGA ITLELASQPV RQFDRYFQSL NPYNNHRNPW FRDFWEQKFQ 360
CSLQNKRNHR RVCDKHLAID SSNYEQESKI MFVVNAVYAM AHALHKMQRT LCPNTTKLCD 420
AMKILDGKKL YKDYLLKINF TAPFNPNKDA DSIVKFDTFG DGMGRYNVFN FQNVGGKYSY 480
LKVGHWAETL SLDVNSIHWS RNSVPTSQCS DPCAPNEMKN MQPGDVCCWI CIPCEPYEYL 540
ADEFTCMDCG SGQWPTADLT GCYDLPEDYI RWEDAWAIGP VTIACLGFMC TCMVVTVFIK 600
HNNTPLVKAS GRELCYILLF GVGLSYCMTF FFIAKPSPVI CALRRLGLGS SFAICYSALL 660
TKTNCIARIF DGVKNGAQRP KFISPSSQVF ICLGLILVQI VMVSVWLILE APGTRRYTLA 720
EKRETVILKC NVKDSSMLIS LTYDVILVIL CTVYAFKTRK CPENFNEAKF IGFTMYTTCI 780
IWLAFLPIFY VTSSDYRVQT TTMCISVSLS GFVVLGCLFA PKVHIILFQP QKNVVTHRLH 840
LNRFSVSGTG TTYSQSSAST YVPTVCNGRE VLDSTTSSL 879 |
Gene Ontology | GO:0030424; C:axon; IEA:Compara. GO:0005887; C:integral to plasma membrane; TAS:ProtInc. GO:0014069; C:postsynaptic density; IEA:Compara. GO:0045211; C:postsynaptic membrane; IEA:Compara. GO:0042734; C:presynaptic membrane; IEA:Compara. GO:0005246; F:calcium channel regulator activity; IEA:Compara. GO:0004930; F:G-protein coupled receptor activity; TAS:UniProtKB. GO:0008066; F:glutamate receptor activity; TAS:UniProtKB. GO:0001641; F:group II metabotropic glutamate receptor activity; IEA:Compara. GO:0007194; P:negative regulation of adenylate cyclase activity; TAS:ProtInc. GO:0050804; P:regulation of synaptic transmission; IEA:Compara. GO:0007268; P:synaptic transmission; TAS:ProtInc. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |