CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-006186
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Retrograde regulation protein 2 
Protein Synonyms/Alias
  
Gene Name
 RTG2 
Gene Synonyms/Alias
 YGL252C; NRF588 
Created Date
 July 27, 2013 
Organism
 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 
NCBI Taxa ID
 559292 
Lysine Modification
Position
Peptide
Type
References
49RIMPCVFKDRVGLSLubiquitination[1]
Reference
 [1] Global analysis of phosphorylation and ubiquitylation cross-talk in protein degradation.
 Swaney DL, Beltrao P, Starita L, Guo A, Rush J, Fields S, Krogan NJ, Villén J.
 Nat Methods. 2013 Jul;10(7):676-82. [PMID: 23749301] 
Functional Description
 Required for a novel path of interorganelle communication between mitochondria, peroxisomes and the nucleus, thereby maintaining a functional metabolic interaction between the tricarboxylic acid and glyoxylate cycles. In particular, required for the retrograde expression of the peroxisomal isoform of citrate synthase, CIT2. 
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 588 AA 
Protein Sequence
MSTLSDSDTE TEVVSRNLCG IVDIGSNGIR FSISSKAAHH ARIMPCVFKD RVGLSLYEVQ 60
YNTHTNAKCP IPRDIIKEVC SAMKRFKLIC DDFGVPETSV RVIATEATRD AINADEFVNA 120
VYGSTGWKVE ILGQEDETRV GIYGVVSSFN TVRGLYLDVA GGSTQLSWVI SSHGEVKQSS 180
KPVSLPYGAG TLLRRMRTDD NRALFYEIKE AYKDAIEKIG IPQEMIDDAK KEGGFDLWTR 240
GGGLRGMGHL LLYQSEGYPI QTIINGYACT YEEFSSMSDY LFLKQKIPGS SKEHKIFKVS 300
DRRALQLPAV GLFMSAVFEA IPQIKAVHFS EGGVREGSLY SLLPKEIRAQ DPLLIASRPY 360
APLLTEKYLY LLRTSIPQED IPEIVNERIA PALCNLAFVH ASYPKELQPT AALHVATRGI 420
IAGCHGLSHR ARALIGIALC SRWGGNIPES EEKYSQELEQ VVLREGDKAE ALRIVWWTKY 480
IGTIMYVICG VHPGGNIRDN VFDFHVSKRS EVETSLKELI IDDANTTKVK EESTRKNRGY 540
EVVVRISKDD LKTSASVRSR IITLQKKVRK LSRGSVERVK IGVQFYEE 588 
Gene Ontology
 GO:0005737; C:cytoplasm; IDA:SGD.
 GO:0046695; C:SLIK (SAGA-like) complex; IDA:SGD.
 GO:0035327; C:transcriptionally active chromatin; IDA:SGD.
 GO:0001076; F:RNA polymerase II transcription factor binding transcription factor activity; IDA:SGD.
 GO:0035753; P:maintenance of DNA trinucleotide repeats; IMP:SGD.
 GO:0031930; P:mitochondria-nucleus signaling pathway; IMP:SGD.
 GO:1900008; P:negative regulation of extrachromosomal rDNA circle accumulation involved in replicative cell aging; IMP:SGD.
 GO:0001079; P:nitrogen catabolite regulation of transcription from RNA polymerase II promoter; IMP:SGD.
 GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IDA:SGD.
 GO:0042991; P:transcription factor import into nucleus; IMP:SGD. 
Interpro
 IPR003695; Ppx_GppA. 
Pfam
 PF02541; Ppx-GppA 
SMART
  
PROSITE
  
PRINTS