UniProt Accession

 NAA30_HUMAN; Q147X3; Q0IIN2 

Genbank Protein ID

 CH471061; BC118589; BC122557 

Genbank Nucleotide ID

 EAW80705.1; AAI18590.1; AAI22558.1 

Protein Name

 N-alpha-acetyltransferase 30 

Protein Synonyms/Alias

 N-acetyltransferase 12; N-acetyltransferase MAK3 homolog; NatC catalytic subunit 

Gene Name

 NAA30 

Gene Synonyms/Alias

 C14orf35; MAK3; NAT12 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
233	DIMRLITKDLSEPYS	acetylation	[1, 2, 3, 4, 5]

Reference

 [1] Lysine acetylation targets protein complexes and co-regulates major cellular functions.
 Choudhary C, Kumar C, Gnad F, Nielsen ML, Rehman M, Walther TC, Olsen JV, Mann M.
 Science. 2009 Aug 14;325(5942):834-40. [PMID: 19608861]
 [2] Monoclonal antibody cocktail as an enrichment tool for acetylome analysis.
 Shaw PG, Chaerkady R, Zhang Z, Davidson NE, Pandey A.
 Anal Chem. 2011 May 15;83(10):3623-6. [PMID: 21466224]
 [3] Proteomic investigations reveal a role for RNA processing factor THRAP3 in the DNA damage response.
 Beli P, Lukashchuk N, Wagner SA, Weinert BT, Olsen JV, Baskcomb L, Mann M, Jackson SP, Choudhary C.
 Mol Cell. 2012 Apr 27;46(2):212-25. [PMID: 22424773]
 [4] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377]
 [5] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302] 

Functional Description

 Catalytic subunit of the N-terminal acetyltransferase C (NatC) complex. Catalyzes acetylation of the N-terminal methionine residues of peptides beginning with Met-Leu-Ala and Met-Leu-Gly. Necessary for the lysosomal localization and function of ARL8B. 

Sequence Annotation

 DOMAIN 214 362 N-acetyltransferase.
 MOD_RES 39 39 Phosphoserine.
 MOD_RES 55 55 Phosphoserine.
 MOD_RES 117 117 Phosphothreonine.
 MOD_RES 152 152 Phosphoserine.
 MOD_RES 196 196 Phosphoserine.
 MOD_RES 199 199 Phosphoserine.
 MOD_RES 233 233 N6-acetyllysine.  

Keyword

 Acetylation; Acyltransferase; Alternative splicing; Complete proteome; Cytoplasm; Phosphoprotein; Reference proteome; Transferase. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 362 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
 GO:0004596; F:peptide alpha-N-acetyltransferase activity; IEA:EC. 

Interpro

 IPR016181; Acyl_CoA_acyltransferase.
 IPR000182; GNAT_dom. 

Pfam

 PF00583; Acetyltransf_1 

SMART

  

PROSITE

 PS51186; GNAT 

PRINTS