CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-010870
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Uridine 5'-monophosphate synthase 
Protein Synonyms/Alias
 UMP synthase; Rudimentary-like protein; Orotate phosphoribosyltransferase; OPRTase; Orotidine 5'-phosphate decarboxylase; OMPdecase 
Gene Name
 r-l 
Gene Synonyms/Alias
 CG3593 
Created Date
 July 27, 2013 
Organism
 Drosophila melanogaster (Fruit fly) 
NCBI Taxa ID
 7227 
Lysine Modification
Position
Peptide
Type
References
23LFEINAFKFGDFKMKacetylation[1]
166GGVANIAKHGVRMHSacetylation[1]
Reference
 [1] Proteome-wide mapping of the Drosophila acetylome demonstrates a high degree of conservation of lysine acetylation.
 Weinert BT, Wagner SA, Horn H, Henriksen P, Liu WR, Olsen JV, Jensen LJ, Choudhary C.
 Sci Signal. 2011 Jul 26;4(183):ra48. [PMID: 21791702] 
Functional Description
  
Sequence Annotation
 REGION 1 207 OPRTase.
 REGION 208 233 Domain linker.
 REGION 234 493 OMPdecase.
 ACT_SITE 320 320 By similarity.  
Keyword
 Complete proteome; Decarboxylase; Glycosyltransferase; Lyase; Multifunctional enzyme; Pyrimidine biosynthesis; Reference proteome; Transferase. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 493 AA 
Protein Sequence
MVAQNSDKMR ALALKLFEIN AFKFGDFKMK VGINSPVYFD LRVIVSYPDV MQTVSDLLVE 60
HIKDKQLSAK HVCGVPYTAL PLATIVSVQQ GTPMLVRRKE AKAYGTKKLV EGIFNAGDTC 120
LIVEDVVTSG SSILDTVRDL QGEGIVVTDA VVVVDREQGG VANIAKHGVR MHSLFTLSFL 180
LNTLHEAGRI EKSTVEAVAK YIAAVQINSD GTFVGGDKGD VVRANDLQRT KLTYENRANL 240
AKSAVAKRLF NLIASKQTNL CLAADLTHAD EILDVADKCG PYICLLKTHV DIVEDFSDKF 300
IADLQALAQR HNFLLMEDRK FADIGNTVSL QYGKGIYKIS SWADLVTAHT LPGRSILQGL 360
KAGLGEGGAG KERGVFLLAE MSASGNLIDA KYKENSNKIA TEGADVDFVA GVVCQSSDAF 420
AFPGLLQLTP GVKIDEGVDQ LGQQYQSPEH VVKERGADIG VVGRGILKAS SPKQAAQTYR 480
DRLWAAYQDR VAK 493 
Gene Ontology
 GO:0005875; C:microtubule associated complex; IDA:FlyBase.
 GO:0004588; F:orotate phosphoribosyltransferase activity; IMP:FlyBase.
 GO:0004590; F:orotidine-5'-phosphate decarboxylase activity; IMP:FlyBase.
 GO:0006207; P:'de novo' pyrimidine nucleobase biosynthetic process; IC:FlyBase.
 GO:0044205; P:'de novo' UMP biosynthetic process; IEA:UniProtKB-UniPathway. 
Interpro
 IPR013785; Aldolase_TIM.
 IPR014732; OMPdecase.
 IPR018089; OMPdecase_AS.
 IPR001754; OMPdeCOase_dom.
 IPR023031; OPRT.
 IPR004467; Or_phspho_trans_dom.
 IPR000836; PRibTrfase_dom.
 IPR011060; RibuloseP-bd_barrel. 
Pfam
 PF00215; OMPdecase
 PF00156; Pribosyltran 
SMART
 SM00934; OMPdecase 
PROSITE
 PS00156; OMPDECASE
 PS00103; PUR_PYR_PR_TRANSFER 
PRINTS