CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-007920
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Protein BIR1 
Protein Synonyms/Alias
  
Gene Name
 BIR1 
Gene Synonyms/Alias
 YJR089W; J1880 
Created Date
 July 27, 2013 
Organism
 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 
NCBI Taxa ID
 559292 
Lysine Modification
Position
Peptide
Type
References
644RSLSISGKVVPTERKacetylation[1]
878DATLANDKDGDLAFLubiquitination[2]
920FIDDCDKKLDILRRDacetylation[3]
Reference
 [1] Proteome-wide analysis of lysine acetylation suggests its broad regulatory scope in Saccharomyces cerevisiae.
 Henriksen P, Wagner SA, Weinert BT, Sharma S, Bacinskaja G, Rehman M, Juffer AH, Walther TC, Lisby M, Choudhary C.
 Mol Cell Proteomics. 2012 Nov;11(11):1510-22. [PMID: 22865919]
 [2] Global analysis of phosphorylation and ubiquitylation cross-talk in protein degradation.
 Swaney DL, Beltrao P, Starita L, Guo A, Rush J, Fields S, Krogan NJ, Villén J.
 Nat Methods. 2013 Jul;10(7):676-82. [PMID: 23749301]
 [3] mChIP-KAT-MS, a method to map protein interactions and acetylation sites for lysine acetyltransferases.
 Mitchell L, Huard S, Cotrut M, Pourhanifeh-Lemeri R, Steunou AL, Hamza A, Lambert JP, Zhou H, Ning Z, Basu A, Côté J, Figeys DA, Baetz K.
 Proc Natl Acad Sci U S A. 2013 Apr 23;110(17):E1641-50. [PMID: 23572591] 
Functional Description
 Seems to act in the pleiotropic control of cell division. May participate in chromosome segregation events. 
Sequence Annotation
 REPEAT 20 117 BIR 1.
 REPEAT 153 241 BIR 2.
 METAL 208 208 Zinc (By similarity).
 METAL 211 211 Zinc (By similarity).
 METAL 228 228 Zinc (By similarity).
 METAL 237 237 Zinc (By similarity).
 MOD_RES 477 477 Phosphoserine.
 MOD_RES 508 508 Phosphoserine.
 MOD_RES 552 552 Phosphoserine.
 MOD_RES 587 587 Phosphoserine.
 MOD_RES 751 751 Phosphoserine.
 MOD_RES 765 765 Phosphoserine.  
Keyword
 Cell cycle; Cell division; Complete proteome; Metal-binding; Phosphoprotein; Reference proteome; Repeat; Zinc. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 954 AA 
Protein Sequence
MDGQIDKMEK RYSMTKLENR LRTFQDGVAL EKKKLKWSFK VIPYQAMAKL GFYFDPVIDP 60
KTSKLKKDSV RCCYCHRQTY NVRDCRSKRK DVLETLSNIM RQHLTVTDNK QVCLLIYLRN 120
KLLTDYSFHM GVSDWKNDKY FSNPDDENVI NLRKFTFQDN WPHSGSQNEH PLGIEKMVNA 180
GLMRYDSSIE GLGDPSMDKT LMNDTCYCIY CKQLLQGWSI NDDPMSRHYK VSQNGNCYFF 240
QTRNRFERIK NDNDSITKNC EVSPTLGENG KREVINTKTA SQRQCPLFES PPSSTGPQLD 300
DYNEKTDISV IQHNISVLDG AQGENVKRNS VEEKEQINME NGSTTLEEGN INRDVLADKK 360
EVISTPTAKE IKRPNVQLTQ SSSPIKKKRK FKRISPRKIF DEEDSEHSLN NNSANGDNKD 420
KDLVIDFTSH IIKNRDVGRK NAILDDSTDE FSFSNQGHNT FDIPIPTSSH LLKGIDSDND 480
NVIREDDTGI NTDTKGASSK HEKFSVNSEE DLNFSEVKLT GRDSSTNILI RTQIVDQNLG 540
DIDRDKVPNG GSPEVPKTHE LIRDNSEKRE AQNGEFRHQK DSTVRQSPDI LHSNKSGDNS 600
SNITAIPKEE QRRGNSKTSS IPADIHPKPR KNLQEPRSLS ISGKVVPTER KLDNINIDLN 660
FSASDFSPSS QSEQSSKSSS VISTPVASPK INLTRSLHAV KELSGLKKET DDGKYFTNKQ 720
ETIKILEDVS VKNETPNNEM LLFETGTPIA SQENKSRKLF DEEFSGKELD IPIDSSTVEI 780
KKVIKPEFEP VPSVARNLVS GTSSYPRNSR LEEQRKETST SLADNSKKGS SFNEGNNEKE 840
PNAAEWFKID ENRHLVKNYF HDLLKYINNN DATLANDKDG DLAFLIKQMP AEELDMTFNN 900
WVNLKVQSIK REFIDDCDKK LDILRRDYYT ATNFIETLED DNQLIDIAKK MGIL 954 
Gene Ontology
 GO:0032133; C:chromosome passenger complex; IDA:SGD.
 GO:0000778; C:condensed nuclear chromosome kinetochore; IPI:SGD.
 GO:0005874; C:microtubule; IDA:SGD.
 GO:0005739; C:mitochondrion; IDA:SGD.
 GO:0051233; C:spindle midzone; IDA:SGD.
 GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
 GO:0006915; P:apoptotic process; IMP:SGD.
 GO:0051301; P:cell division; IEA:UniProtKB-KW.
 GO:0000022; P:mitotic spindle elongation; IMP:SGD.
 GO:0031134; P:sister chromatid biorientation; IMP:SGD.
 GO:0071173; P:spindle assembly checkpoint; IMP:SGD. 
Interpro
 IPR001370; BIR. 
Pfam
 PF00653; BIR 
SMART
 SM00238; BIR 
PROSITE
 PS01282; BIR_REPEAT_1
 PS50143; BIR_REPEAT_2 
PRINTS