UniProt Accession

 H0VH31_CAVPO; H0VH31 

Genbank Protein ID

 AAKN02021916; AAKN02021917 

Genbank Nucleotide ID

  

Protein Name

 ATP synthase subunit gamma 

Protein Synonyms/Alias

  

Gene Name

 LOC100712939 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Cavia porcellus (Guinea pig) 

NCBI Taxa ID

 10141 

Lysine Modification

Position	Peptide	Type	References
20	TRRLKSIKNIQKITK	acetylation	[1]
30	QKITKSMKMVAAAKY	acetylation	[1]
36	MKMVAAAKYARAERE	acetylation	[1]
45	ARAERELKPARIYGI	acetylation	[1]
60	GSLALYEKADIKVPE	acetylation	[1]
64	LYEKADIKVPEDKKK	acetylation	[1]
69	DIKVPEDKKKHLLIG	acetylation	[1]
70	IKVPEDKKKHLLIGV	acetylation	[1]
71	KVPEDKKKHLLIGVS	acetylation	[1]
96	ASVAKQIKNEVATLT	acetylation	[1]
135	DQFLVTFKDVGRKPP	acetylation	[1]

Reference

 [1] The cardiac acetyl-lysine proteome.
 Foster DB, Liu T, Rucker J, O'Meally RN, Devine LR, Cole RN, O'Rourke B.
 PLoS One. 2013;8(7):e67513. [PMID: 23844019] 

Functional Description

 Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(1) domain and the central stalk which is part of the complex rotary element. The gamma subunit protrudes into the catalytic domain formed of alpha(3)beta(3). Rotation of the central stalk against the surrounding alpha(3)beta(3) subunits leads to hydrolysis of ATP in three separate catalytic sites on the beta subunits (By similarity). 

Sequence Annotation

  

Keyword

 ATP synthesis; CF(1); Complete proteome; Hydrogen ion transport; Ion transport; Reference proteome; Transport. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 278 AA 

Protein Sequence

Gene Ontology

 GO:0005753; C:mitochondrial proton-transporting ATP synthase complex; IEA:Compara.
 GO:0045261; C:proton-transporting ATP synthase complex, catalytic core F(1); IEA:UniProtKB-KW.
 GO:0046933; F:proton-transporting ATP synthase activity, rotational mechanism; IEA:InterPro.
 GO:0046961; F:proton-transporting ATPase activity, rotational mechanism; IEA:InterPro.
 GO:0015986; P:ATP synthesis coupled proton transport; IEA:InterPro. 

Interpro

 IPR000131; ATPase_F1-cplx_gsu.
 IPR023632; ATPase_F1_gsu_CS.
 IPR023633; ATPase_F1_gsu_dom. 

Pfam

 PF00231; ATP-synt 

SMART

  

PROSITE

 PS00153; ATPASE_GAMMA 

PRINTS

 PR00126; ATPASEGAMMA.