UniProt Accession

 SERA_MOUSE; Q61753; Q3TEE5; Q75SV9; Q8C603 

Genbank Protein ID

 AB128936; AK076815; AK169684; BC086668; BC110673; L21027 

Genbank Nucleotide ID

 BAD08449.1; BAC36494.1; BAE41303.1; AAH86668.1; AAI10674.1; AAB67986.1 

Protein Name

 D-3-phosphoglycerate dehydrogenase 

Protein Synonyms/Alias

 3-PGDH; A10 

Gene Name

 Phgdh 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
8	MAFANLRKVLISDSL	acetylation	[1, 2]
8	MAFANLRKVLISDSL	succinylation	[2]
21	SLDPCCRKILQDGGL	acetylation	[1, 2]
21	SLDPCCRKILQDGGL	ubiquitination	[3]
33	GGLQVVEKQNLSKEE	acetylation	[1, 4]
58	LIVRSATKVTADVIN	ubiquitination	[3]
289	PHLGASTKEAQSRCG	acetylation	[4]
394	DVNLVNAKLLVKEAG	acetylation	[1, 2, 4]
394	DVNLVNAKLLVKEAG	succinylation	[2]
394	DVNLVNAKLLVKEAG	ubiquitination	[3]

Reference

 [1] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441]
 [2] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
 Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
 Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337]
 [3] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
 [4] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377] 

Functional Description

  

Sequence Annotation

 NP_BIND 155 156 NAD (By similarity).
 NP_BIND 234 236 NAD (By similarity).
 NP_BIND 283 286 NAD (By similarity).
 ACT_SITE 236 236 By similarity.
 ACT_SITE 265 265 By similarity.
 ACT_SITE 283 283 Proton donor (By similarity).
 BINDING 78 78 NAD (By similarity).
 BINDING 175 175 NAD (By similarity).
 BINDING 207 207 NAD; via carbonyl oxygen (By similarity).
 BINDING 260 260 NAD (By similarity).
 MOD_RES 2 2 N-acetylalanine (By similarity).  

Keyword

 Acetylation; Amino-acid biosynthesis; Complete proteome; Direct protein sequencing; NAD; Oxidoreductase; Reference proteome; Serine biosynthesis. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 533 AA 

Protein Sequence

Gene Ontology

 GO:0051287; F:NAD binding; IEA:InterPro.
 GO:0004617; F:phosphoglycerate dehydrogenase activity; TAS:MGI.
 GO:0070314; P:G1 to G0 transition; IMP:MGI.
 GO:0009448; P:gamma-aminobutyric acid metabolic process; IMP:MGI.
 GO:0021782; P:glial cell development; IMP:MGI.
 GO:0006541; P:glutamine metabolic process; IMP:MGI.
 GO:0006544; P:glycine metabolic process; IMP:MGI.
 GO:0006564; P:L-serine biosynthetic process; IEA:UniProtKB-KW.
 GO:0006563; P:L-serine metabolic process; IMP:MGI.
 GO:0021915; P:neural tube development; IMP:MGI.
 GO:0031175; P:neuron projection development; IMP:MGI.
 GO:0010468; P:regulation of gene expression; IMP:MGI.
 GO:0021510; P:spinal cord development; IMP:MGI.
 GO:0019530; P:taurine metabolic process; IMP:MGI.
 GO:0006566; P:threonine metabolic process; IMP:MGI. 

Interpro

 IPR006236; D-3-Phosphoglycerate_DH.
 IPR006139; D-isomer_2_OHA_DH_cat_dom.
 IPR006140; D-isomer_2_OHA_DH_NAD-bd.
 IPR016040; NAD(P)-bd_dom. 

Pfam

 PF00389; 2-Hacid_dh
 PF02826; 2-Hacid_dh_C 

SMART

  

PROSITE

 PS00065; D_2_HYDROXYACID_DH_1
 PS00670; D_2_HYDROXYACID_DH_2
 PS00671; D_2_HYDROXYACID_DH_3 

PRINTS