CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-043077
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 AP-3 complex subunit sigma-2 
Protein Synonyms/Alias
 Adaptor-related protein complex 3, sigma 2 subunit, isoform CRA_d 
Gene Name
 AP3S2 
Gene Synonyms/Alias
 hCG_27218 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
13LVFNNHGKPRLVRFYubiquitination[1]
161EAQNRLEKSEGGLSAubiquitination[1, 2, 3, 4]
178ARAVSAVKNINLPEIubiquitination[1, 2, 5]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [3] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094]
 [4] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302]
 [5] Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition.
 Udeshi ND, Mani DR, Eisenhaure T, Mertins P, Jaffe JD, Clauser KR, Hacohen N, Carr SA.
 Mol Cell Proteomics. 2012 May;11(5):148-59. [PMID: 22505724
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 205 AA 
Protein Sequence
MIQAILVFNN HGKPRLVRFY QRFPEEIQQQ IVRETFHLVL KRDDNICNFL EGGSLIGGSD 60
YKLIYRHYAT LYFVFCVDSS ESELGILDLI QVHLEVVFFI APKVFVETLD KCFENVCELD 120
LIFHMDKVHY ILQEVVMGGM VLETNMNEIV AQIEAQNRLE KSEGGLSAAP ARAVSAVKNI 180
NLPEIPRNIN IGDLNIKVPN LSQFV 205 
Gene Ontology
 GO:0030123; C:AP-3 adaptor complex; IEA:InterPro.
 GO:0008565; F:protein transporter activity; IEA:InterPro.
 GO:0006886; P:intracellular protein transport; IEA:InterPro.
 GO:0016192; P:vesicle-mediated transport; IEA:InterPro. 
Interpro
 IPR016635; AP_complex_ssu.
 IPR022775; AP_mu_sigma_su.
 IPR027155; APS3.
 IPR000804; Clathrin_sm-chain_CS.
 IPR011012; Longin-like_dom. 
Pfam
 PF01217; Clat_adaptor_s 
SMART
  
PROSITE
 PS00989; CLAT_ADAPTOR_S 
PRINTS