| Tag | Content |
|---|
| CPLM ID | CPLM-003792 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Protein translocase subunit SecA |
Protein Synonyms/Alias | |
Gene Name | secA |
Gene Synonyms/Alias | azi; pea; prlD; b0098; JW0096 |
Created Date | July 27, 2013 |
Organism | Escherichia coli (strain K12) |
NCBI Taxa ID | 83333 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 8 | MLIKLLTKVFGSRND | acetylation | [1] | | 23 | RTLRRMRKVVNIINA | acetylation | [1] | | 37 | AMEPEMEKLSDEELK | acetylation | [1] | | 44 | KLSDEELKGKTAEFR | acetylation | [1] | | 56 | EFRARLEKGEVLENL | acetylation | [1] | | 124 | YLNALTGKGVHVVTV | acetylation | [1] | | 237 | EDSSEMYKRVNKIIP | acetylation | [1] | | 241 | EMYKRVNKIIPHLIR | acetylation | [1] | | 268 | GHFSVDEKSRQVNLT | acetylation | [1] | | 329 | RDVDYIVKDGEVIIV | acetylation | [1] | | 443 | QAIIEDIKERTAKGQ | acetylation | [1] | | 471 | LVSNELTKAGIKHNV | acetylation | [1] | | 482 | KHNVLNAKFHANEAA | acetylation | [1] | | 613 | MMRKLGMKPGEAIEH | acetylation | [1] | | 625 | IEHPWVTKAIANAQR | acetylation | [1] | | 726 | PIAEWLDKEPELHEE | acetylation | [1] | | 764 | EMMRHFEKGVMLQTL | acetylation | [1] | | 797 | HLRGYAQKDPKQEYK | acetylation | [1] | | 800 | GYAQKDPKQEYKRES | acetylation | [1] |
|
Reference | [1] Acetyl-Phosphate Is a Critical Determinant of Lysine Acetylation in E. coli. Weinert BT, Iesmantavicius V, Wagner SA, Schölz C, Gummesson B, Beli P, Nyström T, Choudhary C. Mol Cell. 2013 Jul 25;51(2):265-72. [ PMID: 23830618] |
Functional Description | Required for protein export, interacts with the SecYEG preprotein conducting channel. SecA has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving both as a receptor for the preprotein- SecB complex and as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane. |
Sequence Annotation | NP_BIND 102 109 ATP (Potential).
METAL 885 885 Zinc.
METAL 887 887 Zinc.
METAL 896 896 Zinc.
METAL 897 897 Zinc. |
Keyword | 3D-structure; ATP-binding; Cell inner membrane; Cell membrane; Complete proteome; Cytoplasm; Direct protein sequencing; Membrane; Metal-binding; Nucleotide-binding; Protein transport; Reference proteome; Translocation; Transport; Zinc. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 901 AA |
Protein Sequence | MLIKLLTKVF GSRNDRTLRR MRKVVNIINA MEPEMEKLSD EELKGKTAEF RARLEKGEVL 60
ENLIPEAFAV VREASKRVFG MRHFDVQLLG GMVLNERCIA EMRTGEGKTL TATLPAYLNA 120
LTGKGVHVVT VNDYLAQRDA ENNRPLFEFL GLTVGINLPG MPAPAKREAY AADITYGTNN 180
EYGFDYLRDN MAFSPEERVQ RKLHYALVDE VDSILIDEAR TPLIISGPAE DSSEMYKRVN 240
KIIPHLIRQE KEDSETFQGE GHFSVDEKSR QVNLTERGLV LIEELLVKEG IMDEGESLYS 300
PANIMLMHHV TAALRAHALF TRDVDYIVKD GEVIIVDEHT GRTMQGRRWS DGLHQAVEAK 360
EGVQIQNENQ TLASITFQNY FRLYEKLAGM TGTADTEAFE FSSIYKLDTV VVPTNRPMIR 420
KDLPDLVYMT EAEKIQAIIE DIKERTAKGQ PVLVGTISIE KSELVSNELT KAGIKHNVLN 480
AKFHANEAAI VAQAGYPAAV TIATNMAGRG TDIVLGGSWQ AEVAALENPT AEQIEKIKAD 540
WQVRHDAVLE AGGLHIIGTE RHESRRIDNQ LRGRSGRQGD AGSSRFYLSM EDALMRIFAS 600
DRVSGMMRKL GMKPGEAIEH PWVTKAIANA QRKVESRNFD IRKQLLEYDD VANDQRRAIY 660
SQRNELLDVS DVSETINSIR EDVFKATIDA YIPPQSLEEM WDIPGLQERL KNDFDLDLPI 720
AEWLDKEPEL HEETLRERIL AQSIEVYQRK EEVVGAEMMR HFEKGVMLQT LDSLWKEHLA 780
AMDYLRQGIH LRGYAQKDPK QEYKRESFSM FAAMLESLKY EVISTLSKVQ VRMPEEVEEL 840
EQQRRMEAER LAQMQQLSHQ DDDSAAAAAL AAQTGERKVG RNDPCPCGSG KKYKQCHGRL 900
Q 901 |
Gene Ontology | GO:0005737; C:cytoplasm; IDA:EcoliWiki. GO:0005886; C:plasma membrane; IDA:EcoliWiki. GO:0005524; F:ATP binding; IEA:HAMAP. GO:0046872; F:metal ion binding; IEA:UniProtKB-KW. GO:0065002; P:intracellular protein transmembrane transport; IMP:EcoliWiki. GO:0017038; P:protein import; IEA:InterPro. GO:0006605; P:protein targeting; IMP:EcoliWiki. GO:0043952; P:protein transport by the Sec complex; IMP:EcoliWiki. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |