CPLM-001450

CPLM 1.0 - Compendium of Protein Lysine Modification

Tag

Content

CPLM ID

CPLM-001450

UniProt Accession

LANC1_MOUSE; O89112

Genbank Protein ID

Y11550; Y16518; AJ294535; AJ289603; AJ289604; AJ289605; AJ289606; AJ289607; AJ289608; BC058560

Genbank Nucleotide ID

CAA72314.1; CAA76269.1; CAC69241.1; CAC40153.1; CAC40153.1; CAC40153.1; CAC40153.1; CAC40153.1; CAC40153.1; AAH58560.1

Protein Name

LanC-like protein 1

Protein Synonyms/Alias

40 kDa erythrocyte membrane protein; p40

Gene Name

Lancl1

Gene Synonyms/Alias

Gpr69a

Created Date

July 27, 2013

Organism

Mus musculus (Mouse)

NCBI Taxa ID

10090

Lysine Modification

Position	Peptide	Type	References
15	NPYADYNKSLAENYF	ubiquitination	[1]

Reference

[1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]

Functional Description

May play a role in EPS8 signaling. Binds glutathion (By similarity).

Sequence Annotation

REGION 364 367 Glutathione binding (By similarity).
METAL 276 276 Zinc (By similarity).
METAL 322 322 Zinc (By similarity).
METAL 323 323 Zinc (By similarity).
BINDING 317 317 Glutathione (By similarity).
MOD_RES 2 2 N-acetylalanine (By similarity).
MOD_RES 142 142 N6-acetyllysine (By similarity).

Keyword

Acetylation; Complete proteome; Cytoplasm; Membrane; Metal-binding; Nucleus; Reference proteome; Zinc.

Sequence Source

UniProt (SWISSPROT/TrEMBL); GenBank; EMBL

Protein Length

399 AA

Protein Sequence

MAQRAFPNPY ADYNKSLAEN YFDSTGRLTP EFSHRLTNKI RELLQQMERG LKSADPRDGT 60
GYTGWAGIAV LYLHLHNVFG DPAYLQMAHS YVKQSLNCLS RRSITFLCGD AGPLAVAAVL 120
YHKMNSEKQA EECITRLIHL NKIDPHVPNE MLYGRIGYIF ALLFVNKNFG EEKIPQSHIQ 180
QICENILTSG ENLSRKRNLA AKSPLMYEWY QEYYVGAAHG LAGIYYYLMQ PSLQVNQGKL 240
HSLVKPSVDF VCRLKFPSGN YPPCLDDTRD LLVHWCHGAP GVIYMLIQAY KVFKEERYLC 300
DAQQCADVIW QYGLLKKGYG LCHGAAGNAY AFLALYNLTQ DLKYLYRACK FAEWCLDYGE 360
HGCRTADTPF SLFEGMAGTI YFLADLLVPT KAKFPAFEL 399

Gene Ontology

GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
GO:0015630; C:microtubule cytoskeleton; IEA:Compara.
GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
GO:0003824; F:catalytic activity; IEA:InterPro.
GO:0043295; F:glutathione binding; ISS:UniProtKB.
GO:0050750; F:low-density lipoprotein particle receptor binding; ISO:MGI.
GO:0008270; F:zinc ion binding; ISS:UniProtKB.
GO:0008152; P:metabolic process; IEA:GOC.

Interpro

IPR008928; 6-hairpin_glycosidase-like.
IPR012341; 6hp_glycosidase.
IPR007822; LANC-like.
IPR020464; LanC-like_prot_euk.

Pfam

PF05147; LANC_like

SMART

PROSITE

PRINTS

PR01951; LANCEUKARYTE.
PR01950; LANCSUPER.