UniProt Accession

 DXR_ECOLI; P45568; P77209; Q8KMY5 

Genbank Protein ID

 AB013300; U70214; U00096; AP009048; D13334 

Genbank Nucleotide ID

 BAA32426.1; AAB08602.1; AAC73284.1; BAA77848.2 

Protein Name

 1-deoxy-D-xylulose 5-phosphate reductoisomerase 

Protein Synonyms/Alias

 DXP reductoisomerase; 1-deoxyxylulose-5-phosphate reductoisomerase; 2-C-methyl-D-erythritol 4-phosphate synthase 

Gene Name

 dxr 

Gene Synonyms/Alias

 ispC; yaeM; b0173; JW0168 

Created Date

 July 27, 2013 

Organism

 Escherichia coli (strain K12) 

NCBI Taxa ID

 83333 

Lysine Modification

Position	Peptide	Type	References
63	MDDEASAKLLKTMLQ	acetylation	[1]

Reference

 [1] Acetyl-Phosphate Is a Critical Determinant of Lysine Acetylation in E. coli.
 Weinert BT, Iesmantavicius V, Wagner SA, Schölz C, Gummesson B, Beli P, Nyström T, Choudhary C.
 Mol Cell. 2013 Jul 25;51(2):265-72. [PMID: 23830618] 

Functional Description

 Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP). 

Sequence Annotation

 NP_BIND 7 36 NADP.
 REGION 222 228 Binding to substrate phosphate group.
 METAL 150 150 Divalent metal cation.
 METAL 152 152 Divalent metal cation.
 METAL 231 231 Divalent metal cation.
 BINDING 125 125 Substrate.
 BINDING 152 152 Substrate.
 BINDING 186 186 Substrate.
 BINDING 209 209 Substrate.
 BINDING 231 231 Substrate.  

Keyword

 3D-structure; Cobalt; Complete proteome; Isoprene biosynthesis; Magnesium; Manganese; Metal-binding; NADP; Oxidoreductase; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 398 AA 

Protein Sequence

Gene Ontology

 GO:0030604; F:1-deoxy-D-xylulose-5-phosphate reductoisomerase activity; IDA:EcoCyc.
 GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
 GO:0070402; F:NADPH binding; IEA:InterPro.
 GO:0019288; P:isopentenyl diphosphate biosynthetic process, mevalonate-independent pathway; IEA:UniProtKB-UniPathway.
 GO:0016114; P:terpenoid biosynthetic process; IEA:HAMAP.
 GO:0006744; P:ubiquinone biosynthetic process; IDA:EcoCyc. 

Interpro

 IPR003821; DXP_reductoisomerase.
 IPR013644; DXP_reductoisomerase_C.
 IPR013512; DXP_reductoisomerase_N.
 IPR026877; DXPR_C.
 IPR016040; NAD(P)-bd_dom. 

Pfam

 PF08436; DXP_redisom_C
 PF02670; DXP_reductoisom
 PF13288; DXPR_C 

SMART

  

PROSITE

  

PRINTS