CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-017717
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 TNFAIP3-interacting protein 2 
Protein Synonyms/Alias
 A20-binding inhibitor of NF-kappa-B activation 2; ABIN-2; Fetal liver LKB1-interacting protein 
Gene Name
 TNIP2 
Gene Synonyms/Alias
 ABIN2; FLIP1 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
121QPQHEREKEVVLLRRubiquitination[1]
170HMCQHLAKCLDERQHubiquitination[1]
279INDCAEVKQELAASRubiquitination[1, 2]
330RIQELEEKVASLLHQubiquitination[1]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302] 
Functional Description
 Inhibits NF-kappa-B activation by blocking the interaction of RIPK1 with its downstream effector NEMO/IKBKG. Forms a ternary complex with NFKB1 and MAP3K8 but appears to function upstream of MAP3K8 in the TLR4 signaling pathway that regulates MAP3K8 activation. Involved in activation of the MEK/ERK signaling pathway during innate immune response; this function seems to be stimulus- and cell type specific. Required for stability of MAP3K8. Involved in regulation of apoptosis in endothelial cells; promotes TEK agonist-stimulated endothelial survival. May act as transcriptional coactivator when translocated to the nucleus. Enhances CHUK-mediated NF-kappa-B activation involving NF-kappa-B p50-p65 and p50-c-Rel complexes. 
Sequence Annotation
 REGION 289 347 Ubiquitin-binding domain (UBD).  
Keyword
 Alternative splicing; Apoptosis; Coiled coil; Complete proteome; Cytoplasm; Inflammatory response; Nucleus; Phosphoprotein; Polymorphism; Reference proteome; Transcription; Transcription regulation; Ubl conjugation. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 429 AA 
Protein Sequence
MSRDPGSGGW EEAPRAAAAL CTLYHEAGQR LRRLQDQLAA RDALIARLRA RLAALEGDAA 60
PSLVDALLEQ VARFREQLRR QEGGAAEAQM RQEIERLTER LEEKEREMQQ LLSQPQHERE 120
KEVVLLRRSM AEGERARAAS DVLCRSLANE THQLRRTLTA TAHMCQHLAK CLDERQHAQR 180
NVGERSPDQS EHTDGHTSVQ SVIEKLQEEN RLLKQKVTHV EDLNAKWQRY NASRDEYVRG 240
LHAQLRGLQI PHEPELMRKE ISRLNRQLEE KINDCAEVKQ ELAASRTARD AALERVQMLE 300
QQILAYKDDF MSERADRERA QSRIQELEEK VASLLHQVSW RQDSREPDAG RIHAGSKTAK 360
YLAADALELM VPGGWRPGTG SQQPEPPAEG GHPGAAQRGQ GDLQCPHCLQ CFSDEQGEEL 420
LRHVAECCQ 429 
Gene Ontology
 GO:0005829; C:cytosol; TAS:Reactome.
 GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
 GO:0031593; F:polyubiquitin binding; IDA:UniProtKB.
 GO:0019901; F:protein kinase binding; IDA:UniProtKB.
 GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.
 GO:0023035; P:CD40 signaling pathway; ISS:UniProtKB.
 GO:0071222; P:cellular response to lipopolysaccharide; ISS:UniProtKB.
 GO:0007249; P:I-kappaB kinase/NF-kappaB cascade; IEA:Compara.
 GO:0006954; P:inflammatory response; IEA:UniProtKB-KW.
 GO:0070498; P:interleukin-1-mediated signaling pathway; ISS:UniProtKB.
 GO:2000352; P:negative regulation of endothelial cell apoptotic process; IDA:UniProtKB.
 GO:0050871; P:positive regulation of B cell activation; ISS:UniProtKB.
 GO:0043123; P:positive regulation of I-kappaB kinase/NF-kappaB cascade; IDA:UniProtKB.
 GO:0043032; P:positive regulation of macrophage activation; ISS:UniProtKB.
 GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IDA:UniProtKB.
 GO:0050821; P:protein stabilization; ISS:UniProtKB.
 GO:0034134; P:toll-like receptor 2 signaling pathway; ISS:UniProtKB.
 GO:0034138; P:toll-like receptor 3 signaling pathway; ISS:UniProtKB.
 GO:0034162; P:toll-like receptor 9 signaling pathway; ISS:UniProtKB.
 GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. 
Interpro
 IPR022008; EABR. 
Pfam
 PF12180; EABR 
SMART
  
PROSITE
  
PRINTS