UniProt Accession

 SERA_ECOLI; P0A9T0; P08328; Q2M9S9; Q47633 

Genbank Protein ID

 L29397; U28377; U00096; AP009048; X66836; M64630 

Genbank Nucleotide ID

 AAA24625.1; AAA69080.1; AAC75950.1; BAE76977.1; CAA47308.1; AAA73016.1 

Protein Name

 D-3-phosphoglycerate dehydrogenase 

Protein Synonyms/Alias

 PGDH 

Gene Name

 serA 

Gene Synonyms/Alias

 b2913; JW2880 

Created Date

 July 27, 2013 

Organism

 Escherichia coli (strain K12) 

NCBI Taxa ID

 83333 

Lysine Modification

Position	Peptide	Type	References
8	MAKVSLEKDKIKFLL	acetylation	[1]
10	KVSLEKDKIKFLLVE	acetylation	[1]
12	SLEKDKIKFLLVEGV	acetylation	[1]
22	LVEGVHQKALESLRA	acetylation	[1]
39	YTNIEFHKGALDDEQ	acetylation	[1, 2, 3]
48	ALDDEQLKESIRDAH	acetylation	[1]
141	AHRGVWNKLAAGSFE	acetylation	[1]
218	VPENPSTKNMMGAKE	acetylation	[1]
224	TKNMMGAKEISLMKP	acetylation	[1]
230	AKEISLMKPGSLLIN	acetylation	[1]
314	EVAGKLIKYSDNGST	acetylation	[1]
398	EKALQAMKAIPGTIR	acetylation	[1, 3]

Reference

 [1] Acetyl-Phosphate Is a Critical Determinant of Lysine Acetylation in E. coli.
 Weinert BT, Iesmantavicius V, Wagner SA, Schölz C, Gummesson B, Beli P, Nyström T, Choudhary C.
 Mol Cell. 2013 Jul 25;51(2):265-72. [PMID: 23830618]
 [2] The diversity of lysine-acetylated proteins in Escherichia coli.
 Yu BJ, Kim JA, Moon JH, Ryu SE, Pan JG.
 J Microbiol Biotechnol. 2008 Sep;18(9):1529-36. [PMID: 18852508]
 [3] Comprehensive profiling of protein lysine acetylation in Escherichia coli.
 Zhang K, Zheng S, Yang JS, Chen Y, Cheng Z.
 J Proteome Res. 2013 Feb 1;12(2):844-51. [PMID: 23294111] 

Functional Description

  

Sequence Annotation

 DOMAIN 339 410 ACT.
 NP_BIND 161 162 NAD (By similarity).
 NP_BIND 238 240 NAD (By similarity).
 NP_BIND 292 295 NAD (By similarity).
 ACT_SITE 240 240
 ACT_SITE 269 269
 ACT_SITE 292 292 Proton donor.
 BINDING 181 181 NAD (By similarity).
 BINDING 264 264 NAD (By similarity).  

Keyword

 3D-structure; Amino-acid biosynthesis; Complete proteome; Direct protein sequencing; NAD; Oxidoreductase; Reference proteome; Serine biosynthesis. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 410 AA 

Protein Sequence

Gene Ontology

 GO:0047545; F:2-hydroxyglutarate dehydrogenase activity; IDA:EcoCyc.
 GO:0016597; F:amino acid binding; IEA:InterPro.
 GO:0051287; F:NAD binding; IEA:InterPro.
 GO:0004617; F:phosphoglycerate dehydrogenase activity; IDA:EcoCyc.
 GO:0006564; P:L-serine biosynthetic process; IMP:EcoCyc. 

Interpro

 IPR002912; ACT_dom.
 IPR006139; D-isomer_2_OHA_DH_cat_dom.
 IPR006140; D-isomer_2_OHA_DH_NAD-bd.
 IPR016040; NAD(P)-bd_dom. 

Pfam

 PF00389; 2-Hacid_dh
 PF02826; 2-Hacid_dh_C
 PF01842; ACT 

SMART

  

PROSITE

 PS51671; ACT
 PS00065; D_2_HYDROXYACID_DH_1
 PS00670; D_2_HYDROXYACID_DH_2
 PS00671; D_2_HYDROXYACID_DH_3 

PRINTS