CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-031841
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Dihydrolipoamid dehydrogenase, putative 
Protein Synonyms/Alias
 Dihydrolipoyl dehydrogenase protein, putative 
Gene Name
 TGME49_105980, TGVEG_107420 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Toxoplasma gondii 
NCBI Taxa ID
 5811 
Lysine Modification
Position
Peptide
Type
References
360RLLPGVDKEVAKLAEacetylation[1, 2]
364GVDKEVAKLAERLLLacetylation[2]
375RLLLQQFKERPVKLYacetylation[2]
547KDGFEVGKSVSHFRAacetylation[1]
Reference
 [1] Lysine acetylation is widespread on proteins of diverse function and localization in the protozoan parasite Toxoplasma gondii.
 Jeffers V, Sullivan WJ Jr.
 Eukaryot Cell. 2012 Jun;11(6):735-42. [PMID: 22544907]
 [2] Protein intrinsic disorder in the acetylome of intracellular and extracellular Toxoplasma gondii.
 Xue B, Jeffers V, Sullivan WJ, Uversky VN.
 Mol Biosyst. 2013 Apr 5;9(4):645-57. [PMID: 23403842] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; FAD; Flavoprotein; Oxidoreductase; Redox-active center; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 636 AA 
Protein Sequence
MFFALCLGRA VGRGFLGVSP PAWRGLFAGE TFGPCLRLTA LLCILTTGVI TLSAAFSVQR 60
SAVVSQTFPV PLSVSTASTQ PHVAFVPSPA SPFSLRASLQ ESPGVLTPPP HYASLSSPQP 120
RSEGVSRLFA TSSSTNFSDE PFDVTIIGLG VGGHAAALHA AALGLKTAVV SGGDPGGTCV 180
NRGCVPSKAL LAAARRVKML RNKHHLSAMG LQVEGEIKVD PTGVGNHARG VVDKVRSGLV 240
SSLASHGIAL FDARGVMDGE PGRVVLERTA GSPASLPPFL RTKNVILAPG SLPFIPAGTK 300
EEQFSVMTSD TCVSLPWLPS EICIVGSGYI GLEFMDVFTS LGSEVVMVEA GPRLLPGVDK 360
EVAKLAERLL LQQFKERPVK LYTNTLASQV RPLGPKGEAP VEVQLTDAQT KESKGKIYPD 420
ACLIATGRRP NTEGLGLDSL GVTLKRGGFI PVDACMRVLK HAPEGDEKPE VIRGVYCVGD 480
ANGQMMLAHA ASAQAVAAVE TIAGRPRTVN VKHIPAACFT SPEIAFIGDT EEAAMELGAK 540
DGFEVGKSVS HFRANTKAIA EGEGEGILKV LYRKDTGKIL GCHMIGIHAS DLIQECATAI 600
TNDISVKDLA FTVHTHPTLS EVVDAAWKKA VGMNAH 636 
Gene Ontology
 GO:0005737; C:cytoplasm; IEA:InterPro.
 GO:0004148; F:dihydrolipoyl dehydrogenase activity; IEA:EC.
 GO:0050660; F:flavin adenine dinucleotide binding; IEA:InterPro.
 GO:0045454; P:cell redox homeostasis; IEA:InterPro. 
Interpro
 IPR016156; FAD/NAD-linked_Rdtase_dimer.
 IPR013027; FAD_pyr_nucl-diS_OxRdtase.
 IPR004099; Pyr_nucl-diS_OxRdtase_dimer.
 IPR023753; Pyr_nucl-diS_OxRdtase_FAD/NAD.
 IPR012999; Pyr_OxRdtase_I_AS.
 IPR001327; Pyr_OxRdtase_NAD-bd_dom. 
Pfam
 PF00070; Pyr_redox
 PF07992; Pyr_redox_2
 PF02852; Pyr_redox_dim 
SMART
  
PROSITE
 PS00076; PYRIDINE_REDOX_1 
PRINTS
 PR00368; FADPNR.