UniProt Accession

 GDIA_RAT; P50398; Q499U0; Q9R274 

Genbank Protein ID

 X74402; U07952; BC099763; AF130987 

Genbank Nucleotide ID

 CAA52413.1; AAB16909.1; AAH99763.1; AAD25536.1 

Protein Name

 Rab GDP dissociation inhibitor alpha 

Protein Synonyms/Alias

 Rab GDI alpha; Guanosine diphosphate dissociation inhibitor 1; GDI-1 

Gene Name

 Gdi1 

Gene Synonyms/Alias

 Rabgdia 

Created Date

 July 27, 2013 

Organism

 Rattus norvegicus (Rat) 

NCBI Taxa ID

 10116 

Lysine Modification

Position	Peptide	Type	References
54	TPLEELYKRFQLLEG	acetylation	[1]
54	TPLEELYKRFQLLEG	ubiquitination	[2]
112	VEGSFVYKGGKIYKV	acetylation	[1]
174	SMRDVYRKFDLGQDV	acetylation	[1]
210	LETINRIKLYSESLA	methylation	[3]
221	ESLARYGKSPYLYPL	acetylation	[1]
253	GGTYMLNKPVDDIIM	acetylation	[1]
264	DIIMENGKVVGVKSE	methylation	[3]
269	NGKVVGVKSEGEVAR	acetylation	[1]
269	NGKVVGVKSEGEVAR	methylation	[3]
435	AFDFENMKRKQNDVF	acetylation	[1]
437	DFENMKRKQNDVFGE	ubiquitination	[2]

Reference

 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405]
 [2] Synaptic protein ubiquitination in rat brain revealed by antibody-based ubiquitome analysis.
 Na CH, Jones DR, Yang Y, Wang X, Xu Y, Peng J.
 J Proteome Res. 2012 Sep 7;11(9):4722-32. [PMID: 22871113]
 [3] A method for the comprehensive proteomic analysis of membrane proteins.
 Wu CC, MacCoss MJ, Howell KE, Yates JR 3rd.
 Nat Biotechnol. 2003 May;21(5):532-8. [PMID: 12692561] 

Functional Description

 Regulates the GDP/GTP exchange reaction of most Rab proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP to them. 

Sequence Annotation

 MOD_RES 339 339 Phosphotyrosine (By similarity).  

Keyword

 Complete proteome; Cytoplasm; Direct protein sequencing; GTPase activation; Phosphoprotein; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 447 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
 GO:0030496; C:midbody; IEA:Compara.
 GO:0043005; C:neuron projection; IDA:RGD.
 GO:0043234; C:protein complex; IDA:RGD.
 GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.
 GO:0005093; F:Rab GDP-dissociation inhibitor activity; IDA:RGD.
 GO:0050771; P:negative regulation of axonogenesis; IDA:UniProtKB.
 GO:0043547; P:positive regulation of GTPase activity; IEA:GOC.
 GO:0015031; P:protein transport; IEA:InterPro.
 GO:0051592; P:response to calcium ion; IDA:RGD. 

Interpro

 IPR018203; GDP_dissociation_inhibitor.
 IPR016040; NAD(P)-bd_dom.
 IPR000806; RabGDI. 

Pfam

 PF00996; GDI 

SMART

  

PROSITE

  

PRINTS

 PR00892; RABGDI.
 PR00891; RABGDIREP.