| Tag | Content |
|---|
| CPLM ID | CPLM-022064 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | CTP synthase 2 |
Protein Synonyms/Alias | CTP synthetase 2; UTP--ammonia ligase 2 |
Gene Name | CTPS2 |
Gene Synonyms/Alias | |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 264 | LEEQSIVKYFKERLH | ubiquitination | [1] |
|
Reference | [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C. Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [ PMID: 21890473] |
Functional Description | Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Constitutes the rate-limiting enzyme in the synthesis of cytosine nucleotides. |
Sequence Annotation | DOMAIN 300 554 Glutamine amidotransferase type-1.
ACT_SITE 399 399 For GATase activity (By similarity).
ACT_SITE 526 526 For GATase activity (By similarity).
ACT_SITE 528 528 For GATase activity (By similarity).
MOD_RES 568 568 Phosphoserine.
MOD_RES 571 571 Phosphoserine.
MOD_RES 574 574 Phosphoserine. |
Keyword | 3D-structure; ATP-binding; Complete proteome; Glutamine amidotransferase; Ligase; Nucleotide-binding; Phosphoprotein; Pyrimidine biosynthesis; Reference proteome. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 586 AA |
Protein Sequence | MKYILVTGGV ISGIGKGIIA SSIGTILKSC GLRVTAIKID PYINIDAGTF SPYEHGEVFV 60
LNDGGEVDLD LGNYERFLDI NLYKDNNITT GKIYQHVINK ERRGDYLGKT VQVVPHITDA 120
VQEWVMNQAK VPVDGNKEEP QICVIELGGT IGDIEGMPFV EAFRQFQFKA KRENFCNIHV 180
SLVPQLSATG EQKTKPTQNS VRALRGLGLS PDLIVCRSST PIEMAVKEKI SMFCHVNPEQ 240
VICIHDVSST YRVPVLLEEQ SIVKYFKERL HLPIGDSASN LLFKWRNMAD RYERLQKICS 300
IALVGKYTKL RDCYASVFKA LEHSALAINH KLNLMYIDSI DLEKITETED PVKFHEAWQK 360
LCKADGILVP GGFGIRGTLG KLQAISWART KKIPFLGVCL GMQLAVIEFA RNCLNLKDAD 420
STEFRPNAPV PLVIDMPEHN PGNLGGTMRL GIRRTVFKTE NSILRKLYGD VPFIEERHRH 480
RFEVNPNLIK QFEQNDLSFV GQDVDGDRME IIELANHPYF VGVQFHPEFS SRPMKPSPPY 540
LGLLLAATGN LNAYLQQGCK LSSSDRYSDA SDDSFSEPRI AELEIS 586 |
Gene Ontology | GO:0005829; C:cytosol; TAS:Reactome. GO:0005739; C:mitochondrion; IEA:Compara. GO:0005524; F:ATP binding; IEA:UniProtKB-KW. GO:0003883; F:CTP synthase activity; EXP:Reactome. GO:0044210; P:'de novo' CTP biosynthetic process; IEA:UniProtKB-UniPathway. GO:0006541; P:glutamine metabolic process; IEA:UniProtKB-KW. GO:0015949; P:nucleobase-containing small molecule interconversion; TAS:Reactome. GO:0006220; P:pyrimidine nucleotide metabolic process; TAS:ProtInc. |
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