CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-019507
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Putative methyltransferase NSUN5 
Protein Synonyms/Alias
 NOL1-related protein; NOL1R; NOL1/NOP2/Sun domain family member 5; Williams-Beuren syndrome chromosomal region 20A protein 
Gene Name
 NSUN5 
Gene Synonyms/Alias
 WBSCR20; WBSCR20A 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
22ESRQGSIKGLVYSSNubiquitination[1]
82VYELLLGKGFRGGGGubiquitination[1]
Reference
 [1] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789] 
Functional Description
 May have S-adenosyl-L-methionine-dependent methyl- transferase activity (Potential). 
Sequence Annotation
 REGION 234 240 S-adenosyl-L-methionine binding.
 REGION 285 286 S-adenosyl-L-methionine binding.
 ACT_SITE 359 359 Nucleophile (Potential).
 BINDING 258 258 S-adenosyl-L-methionine.
 BINDING 263 263 S-adenosyl-L-methionine.
 BINDING 305 305 S-adenosyl-L-methionine.
 MOD_RES 2 2 N-acetylglycine.
 MOD_RES 167 167 Phosphoserine.  
Keyword
 3D-structure; Acetylation; Alternative splicing; Complete proteome; Direct protein sequencing; Methyltransferase; Phosphoprotein; Polymorphism; Reference proteome; S-adenosyl-L-methionine; Transferase; Williams-Beuren syndrome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 429 AA 
Protein Sequence
MGLYAAAAGV LAGVESRQGS IKGLVYSSNF QNVKQLYALV CETQRYSAVL DAVIASAGLL 60
RAEKKLRPHL AKVLVYELLL GKGFRGGGGR WKALLGRHQA RLKAELARLK VHRGVSRNED 120
LLEVGSRPGP ASQLPRFVRV NTLKTCSDDV VDYFKRQGFS YQGRASSLDD LRALKGKHFL 180
LDPLMPELLV FPAQTDLHEH PLYRAGHLIL QDRASCLPAM LLDPPPGSHV IDACAAPGNK 240
TSHLAALLKN QGKIFAFDLD AKRLASMATL LARAGVSCCE LAEEDFLAVS PSDPRYHEVH 300
YILLDPSCSG SGMPSRQLEE PGAGTPSPVR LHALAGFQQR ALCHALTFPS LQRLVYSTCS 360
LCQEENEDVV RDALQQNPGA FRLAPALPAW PHRGLSTFPG AEHCLRASPE TTLSSGFFVA 420
VIERVEVPSL TGQSISTRTH TQPSPKEKEE TAKSRSRCLH TALHIAEAPG 470 
Gene Ontology
 GO:0008168; F:methyltransferase activity; IEA:UniProtKB-KW. 
Interpro
 IPR001678; Fmu/NOL1/Nop2p.
 IPR023267; RCMT. 
Pfam
 PF01189; Nol1_Nop2_Fmu 
SMART
  
PROSITE
 PS01153; NOL1_NOP2_SUN 
PRINTS
 PR02008; RCMTFAMILY.