UniProt Accession

 SCOT1_MOUSE; Q9D0K2; Q3TIW6; Q9CV92 

Genbank Protein ID

 AB085609; AK009027; AK011354; AK151662; AK167681; BC003422 

Genbank Nucleotide ID

 BAC05524.1; BAB26035.1; BAB27562.1; BAE30590.1; BAE39730.1; AAH03422.1 

Protein Name

 Succinyl-CoA:3-ketoacid coenzyme A transferase 1, mitochondrial 

Protein Synonyms/Alias

 3-oxoacid CoA-transferase 1; Somatic-type succinyl-CoA:3-oxoacid CoA-transferase; SCOT-s 

Gene Name

 Oxct1 

Gene Synonyms/Alias

 Oxct; Scot 

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
421	MIPGKMVKGMGGAMD	ubiquitination	[1]
473	VNRIITEKGVFDVDK	acetylation	[2]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
 [2] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377] 

Functional Description

 Key enzyme for ketone body catabolism. Transfers the CoA moiety from succinate to acetoacetate. Formation of the enzyme-CoA intermediate proceeds via an unstable anhydride species formed between the carboxylate groups of the enzyme and substrate (By similarity). 

Sequence Annotation

 ACT_SITE 344 344 Acyl-thioester intermediate (By
 MOD_RES 170 170 Phosphoserine (By similarity).  

Keyword

 Complete proteome; Direct protein sequencing; Mitochondrion; Phosphoprotein; Reference proteome; Transferase; Transit peptide. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 520 AA 

Protein Sequence

Gene Ontology

 GO:0005759; C:mitochondrial matrix; IEA:UniProtKB-SubCell.
 GO:0005739; C:mitochondrion; IDA:MGI.
 GO:0008260; F:3-oxoacid CoA-transferase activity; IDA:MGI.
 GO:0060612; P:adipose tissue development; IEA:Compara.
 GO:0007420; P:brain development; IEA:Compara.
 GO:0071229; P:cellular response to acid; IEA:Compara.
 GO:0071333; P:cellular response to glucose stimulus; IEA:Compara.
 GO:0007507; P:heart development; IEA:Compara.
 GO:0046952; P:ketone body catabolic process; IMP:MGI.
 GO:0042182; P:ketone catabolic process; IMP:MGI.
 GO:0032024; P:positive regulation of insulin secretion; IEA:Compara.
 GO:0014823; P:response to activity; IEA:Compara.
 GO:0042493; P:response to drug; IEA:Compara.
 GO:0045471; P:response to ethanol; IEA:Compara.
 GO:0009725; P:response to hormone stimulus; IEA:Compara.
 GO:0007584; P:response to nutrient; IEA:Compara.
 GO:0042594; P:response to starvation; IEA:Compara. 

Interpro

 IPR012792; 3-oxoacid_CoA-transf_A.
 IPR012791; 3-oxoacid_CoA-transf_B.
 IPR014388; 3-oxoacid_CoA-transferase.
 IPR004165; CoA_trans_fam_I.
 IPR004164; CoA_transf_AS.
 IPR004163; CoA_transf_BS. 

Pfam

 PF01144; CoA_trans 

SMART

 SM00882; CoA_trans 

PROSITE

 PS01273; COA_TRANSF_1
 PS01274; COA_TRANSF_2 

PRINTS