CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-025393
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Bromodomain-containing protein 4 
Protein Synonyms/Alias
  
Gene Name
 Brd4 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
99LNLPDYYKIIKTPMDubiquitination[1]
1172SLRPEPPKHPENIKAacetylation[2]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
 [2] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
 Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
 Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337] 
Functional Description
  
Sequence Annotation
  
Keyword
 Bromodomain; Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1401 AA 
Protein Sequence
MSTESGPGTR LRNLPVMGDG LETSQMSTTQ AQAQPQPANA ASTNPPPPET SNPNKPKRQT 60
NQLQYLLRVV LKTLWKHQFA WPFQQPVDAV KLNLPDYYKI IKTPMDMGTI KKRLENNYYW 120
NAQECIQDFN TMFTNCYIYN KPGDDIVLMA EALEKLFLQK INELPTEETE IMIVQAKGRG 180
RGRKETGRAA KPGVSTVPNT TQASTSPQTQ TPQQNPPPPV QATTHPFPAV TPDLIAQPPV 240
MTMVPPQPLQ TPSPVPPQPP PPPAPVPQPV QSHPPIIATT PQPVKTKKGV KRKADTTTPT 300
TIDPIHEPPS LAPEPKTAKL GPRRESSRPV KPPKKDVPDS QQHPGPEKSS KISEQLKCCS 360
GILKEMFAKK HAAYAWPFYK PVDVEALGLH DYCDIIKHPM DMSTIKSKLE SREYRDAQEF 420
GADVRLMFSN CYKYNPPDHE VVAMARKLQD VFEMRFAKMP DEPEEPVVTV SSPAVPPPTK 480
VVAPPSSSDS SSDSSSDSDS STDDSEEERA QRLAELQEQL KAVHEQLAAL SQPQQNKPKK 540
KEKDKKEKKK EKHKKKEEVE ENKKSKTKEL PPKKTKKNNS SNSNVSKKEP VPTKTKPPPT 600
YESEEEDKCK PMSYEEKRQL SLDINKLPGE KLGRVVHIIQ SREPSLKNSN PDEIEIDFET 660
LKPSTLRELE RYVTSCLRKK RKPQAEKVDV IAGSSKMKGF SSSESESTSE SSSSDSEDSE 720
TEMAPKSKKK GHTGRDQKKH HHHHHPQMQP APAPVPQQPP PPPQQPPPPP PPQQQQQQPP 780
PPPPPPSMPQ QTAPAMKSSP PPFITAQVPV LEPQLPGSVF DPIGHFTQPI LHLPQPELPP 840
HLPQPPEHST PPHLNQHAVV SPPALHNALP QQPSRPSNRA AALPPKPTRP PAVSPALAQP 900
PLLPQPPMAQ PPQVLLEDEE PPAPPLTSMQ MQLYLQQLQK VQPPTPLLPS VKVQSQPPPP 960
LPPPPHPSVQ QQQLQPQPPP PPPPQPQPPP QQQHQPPPRP VHLPSMPFSA HIQQPPPPPG 1020
QQPTHPPPGQ QPPPPQPAKP QQVIQHHPSP RHHKSDPYSA GHLREAPSPL MIHSPQMPQF 1080
QSLTHQSPPQ QNVQPKKQVK GRAEPQPPGP VMGQGQGCPP ASPAAVPMLS QELRPPSVVQ 1140
PQPLVVVKEE KIHSPIIRSE PFSTSLRPEP PKHPENIKAP VHLPQRPEMK PVDIGRPVIR 1200
PPEQSAPPPG APDKDKQKQE PKTPVAPKKD LKIKNMGSWA SLVQKHPTTP SSTAKSSSDS 1260
FEHFRRAARE KEEREKALKA QAEHAEKEKE RLRQERMRSR EDEDALEQAR RAHEEARRRQ 1320
EQQQQQQQQR QEQQQQQQQA AAVAAASAPQ AQSSQPQSML DQQRELARKR EQERRRREAM 1380
AATIDMNFQS DLLSIFEENL F 1401 
Gene Ontology
 GO:0000794; C:condensed nuclear chromosome; IDA:MGI.
 GO:0000790; C:nuclear chromatin; IDA:MGI.
 GO:0003682; F:chromatin binding; IDA:MGI.
 GO:0003677; F:DNA binding; IDA:MGI.
 GO:0007059; P:chromosome segregation; IMP:MGI.
 GO:0044154; P:histone H3-K14 acetylation; IMP:MGI.
 GO:0043983; P:histone H4-K12 acetylation; IMP:MGI.
 GO:0001833; P:inner cell mass cell proliferation; IMP:MGI.
 GO:0043388; P:positive regulation of DNA binding; IDA:MGI.
 GO:0006468; P:protein phosphorylation; IPI:MGI. 
Interpro
 IPR001487; Bromodomain.
 IPR018359; Bromodomain_CS.
 IPR027353; NET_dom. 
Pfam
 PF00439; Bromodomain 
SMART
 SM00297; BROMO 
PROSITE
 PS00633; BROMODOMAIN_1
 PS50014; BROMODOMAIN_2
 PS51525; NET 
PRINTS
 PR00503; BROMODOMAIN.