UniProt Accession

 ACBD5_HUMAN; Q5T8D3; B3KQ56; D3DRW0; Q5T8D4; Q5T8E1; Q5T8E2; Q86UV1; Q8N6E3; Q9UFB5 

Genbank Protein ID

 AF505653; AK057469; AL160291; AL160291; AL160291; AL160291; AL160291; CH471072; CH471072; CH471072; BC030555; AL133064 

Genbank Nucleotide ID

 AAP30852.1; BAG51918.1; CAI16911.1; CAI16912.1; CAI16913.1; CAI16914.1; CAI16915.1; EAW86062.1; EAW86061.1; EAW86063.1; AAH30555.1; CAB61388.1 

Protein Name

 Acyl-CoA-binding domain-containing protein 5 

Protein Synonyms/Alias

  

Gene Name

 ACBD5 

Gene Synonyms/Alias

 KIAA1996 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
176	LTSTPNAKTVNGKAE	ubiquitination	[1]
460	NVLQRLQKLETLTAL	ubiquitination	[1, 2]

Reference

 [1] Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass.
 Povlsen LK, Beli P, Wagner SA, Poulsen SL, Sylvestersen KB, Poulsen JW, Nielsen ML, Bekker-Jensen S, Mailand N, Choudhary C.
 Nat Cell Biol. 2012 Oct;14(10):1089-98. [PMID: 23000965]
 [2] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789] 

Functional Description

 Binds medium- and long-chain acyl-CoA esters. 

Sequence Annotation

 DOMAIN 41 130 ACB.
 REGION 52 61 Acyl-CoA binding.
 REGION 72 76 Acyl-CoA binding.
 BINDING 98 98 Acyl-CoA.
 BINDING 117 117 Acyl-CoA (By similarity).
 MOD_RES 160 160 Phosphothreonine (By similarity).
 MOD_RES 193 193 Phosphoserine.
 MOD_RES 194 194 Phosphoserine.
 MOD_RES 196 196 Phosphoserine.
 MOD_RES 200 200 Phosphoserine.
 MOD_RES 400 400 Phosphothreonine.
 MOD_RES 428 428 Phosphoserine.
 MOD_RES 441 441 Phosphoserine (By similarity).  

Keyword

 3D-structure; Alternative splicing; Coiled coil; Complete proteome; Lipid-binding; Membrane; Peroxisome; Phosphoprotein; Polymorphism; Reference proteome; Transmembrane; Transmembrane helix; Transport. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 534 AA 

Protein Sequence

Gene Ontology

 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0043231; C:intracellular membrane-bounded organelle; IDA:HPA.
 GO:0005778; C:peroxisomal membrane; IEA:UniProtKB-SubCell.
 GO:0000062; F:fatty-acyl-CoA binding; IEA:InterPro.
 GO:0008289; F:lipid binding; IEA:UniProtKB-KW.
 GO:0006810; P:transport; IEA:UniProtKB-KW. 

Interpro

 IPR022408; Acyl-CoA-binding_prot_CS.
 IPR000582; Acyl-CoA-binding_protein.
 IPR014352; FERM/acyl-CoA-bd_prot_3-hlx.
 IPR016347; M-assoc_diazepam-bd-inh. 

Pfam

 PF00887; ACBP 

SMART

  

PROSITE

 PS00880; ACB_1
 PS51228; ACB_2 

PRINTS

 PR00689; ACOABINDINGP.