CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-023422
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 AF4/FMR2 family member 4 
Protein Synonyms/Alias
 Protein lilliputian; Suppressor of Raf at 2A; Suppressor of sina 2-1 
Gene Name
 lilli 
Gene Synonyms/Alias
 l(2)00632; SS2-1; Su(Raf)2A; CG8817 
Created Date
 July 27, 2013 
Organism
 Drosophila melanogaster (Fruit fly) 
NCBI Taxa ID
 7227 
Lysine Modification
Position
Peptide
Type
References
426VTSPGPVKPLKTEKNacetylation[1]
Reference
 [1] Proteome-wide mapping of the Drosophila acetylome demonstrates a high degree of conservation of lysine acetylation.
 Weinert BT, Wagner SA, Horn H, Henriksen P, Liu WR, Olsen JV, Jensen LJ, Choudhary C.
 Sci Signal. 2011 Jul 26;4(183):ra48. [PMID: 21791702] 
Functional Description
 Has a role in transcriptional regulation. Acts in parallel with the Ras/MAPK and the PI3K/PKB pathways in the control of cell identity and cellular growth. Essential for regulation of the cytoskeleton and cell growth but not for cell proliferation or growth rate. Required specifically for the microtubule-based basal transport of lipid droplets. Plays a partially redundant function downstream of Raf in cell fate specification in the developing eye. Pair-rule protein that regulates embryonic cellularization, gastrulation and segmentation. 
Sequence Annotation
 DNA_BIND 851 863 A.T hook.
 MOD_RES 420 420 Phosphothreonine.
 MOD_RES 450 450 Phosphoserine.
 MOD_RES 452 452 Phosphoserine.
 MOD_RES 821 821 Phosphoserine.
 MOD_RES 822 822 Phosphoserine.
 MOD_RES 871 871 Phosphoserine.
 MOD_RES 873 873 Phosphoserine.
 MOD_RES 1362 1362 Phosphoserine.
 MOD_RES 1364 1364 Phosphothreonine.  
Keyword
 Alternative splicing; Complete proteome; Developmental protein; DNA-binding; Nucleus; Pair-rule protein; Phosphoprotein; Reference proteome; Transcription; Transcription regulation. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1673 AA 
Protein Sequence
MAQQQQQQMQ QQQQHHTSSI NNNNSSSIVL LQQQQPQQQQ QQLDQLQQYN NNLYSQNYNM 60
EEYERRKRRE REKIERQQGI QIDDRETSLF GEPRRLTEGD AEITAALGEF FEAREYINNQ 120
TVGISRSAPG AGNPRLQPNL APQAKSLGHS PSSASSAAGP TAASATTSLP GQQQHYQQQQ 180
RPPTYVKQAD NKPPYNGRGG YPGQPMKNDI PSSSGMAPPR GPPRTSSSNS NSSSVTNNAS 240
SGGVPASTPL GPPLSTQMPN GREKSFLGPP APALHNGTGG RFVPPAASKR PGVGQQPPPP 300
EKDVNKIISD IANIFTVQPL TLIAATPHAP TRENYNLLAP NRQKYAMDIP SSPPSAEPSS 360
LMTPLFAPIT SPIAPLVTTP PQASQMPLGG ATSGTILAGE ALAPLHQLPP TMPKAASGVT 420
SPGPVKPLKT EKNHSLEKQD SCLENDLELS ESEDEQRKKE GRSGGNSSNS SESDSSESGS 480
ESSSKNDLQH HPNHQQHHHQ LQQQQQQQQA TMQQQQVLQQ QHRSQPLTSN GAQNKKFRHE 540
IIARGSNTIT GLLSSSGFGS GGNVGPAGVN SNAVVGTGSG SGGTLSSGGS SSNKTPSPTE 600
SNKWNLSRFF HKPANQTNSE SVSPGNVSMK VPGILPGGAQ IIPESIDVTT AIVKNEKNDM 660
AMEEGEEEDD DEEQQLRYGG GLSVTPVAVK KEAIDAVSEM ALGAIPKTQI KRESAETLLS 720
ARLSDSGTSA SGSSSSSSSS SDSAMGGEVV PMPGPGETLQ LPGVPAAITT VMRVQPTQSQ 780
KAPPSNSVTL TPILPLPTSP KQRQKKPRKK KAITSAPILD SSDDDEPPPK HPGLDHTAVS 840
VQTQPATDTV KKGRGRPRKQ QQSGGSGNLS SASAGSSSQT KGPTLTAAKK PLAKTPLAMS 900
RARKREHSSQ SSSNGNTPTK KVATPQLVAA PLKPTSNTAG SSSSDEDSSS SAESSSKSSS 960
SSSSSDDTET QNTNCRIVKL NKTGAVQKKA LLGSGSSSPS SSGSEAEDQT TRSQVGSGQA 1020
LAQQLPPYKQ LPISQHSQHL SSSDCSSSSG GCTAVCSSSS GEEDEGRREK ERERKPKSDK 1080
NKINTLTRIF NPKEGGAKKQ GQVVIVDLQE EQQQGKLDAA AQPSAPQAPP AAPAAIMAKP 1140
RMTPTQQQQL GAGLASPART TTPHLTSLIC KIDLSKLSRE RIMRLKKLTP AQQNGHLTPK 1200
DQATNAVHVP NGYAGDTNPA AKVKHEHPVK PEPELDAGYE AKFKPGNVKQ EFQLKQERDR 1260
DRERERERER ERERDREREQ PPGRRRKRSS SSSSSPYKEK KRKKEKADQL QMGKELLPVP 1320
VLLPSNNHER MPNHDRLSYD KLQLLHEDAA AVIGDVSAPN GSPTKKLLAM SPLPPPPTVT 1380
VAPATCNEAV QTTPPSATAT SAIAPPVPAT RLIYRSYFDR DVEHPSDDPR KNNQFLQEAI 1440
NRKHAADLER DSFNQVTLYL EAVVYFLLTA DAMERCSSEQ ATNTMYKDTL SLIKFISTKF 1500
RPYQQQSTTN IQHETHNKVA ILSLRCQSLI SLKLYKLRRK DCRAIINSLT DFFRVGRGDI 1560
ANGNTPSSIS PSNSVGSQGS GSNTPPGRIV PPDIHNMLCK QNEFLSYLNS AHELWDQADR 1620
LVRTGNHIDF IRELDHENGP LTLHSTMHEV FRYVQAGLKT LRDAVSHPTH QSQ 1673 
Gene Ontology
 GO:0032783; C:ELL-EAF complex; IPI:FlyBase.
 GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
 GO:0003700; F:sequence-specific DNA binding transcription factor activity; IMP:UniProtKB.
 GO:0042051; P:compound eye photoreceptor development; IGI:FlyBase.
 GO:0000915; P:cytokinesis, actomyosin contractile ring assembly; NAS:FlyBase.
 GO:0007611; P:learning or memory; IMP:FlyBase.
 GO:0042048; P:olfactory behavior; IMP:FlyBase.
 GO:0007366; P:periodic partitioning by pair rule gene; IMP:UniProtKB.
 GO:0008361; P:regulation of cell size; IMP:FlyBase.
 GO:0051493; P:regulation of cytoskeleton organization; IMP:UniProtKB.
 GO:0032368; P:regulation of lipid transport; IMP:UniProtKB.
 GO:0007379; P:segment specification; IMP:FlyBase.
 GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
 GO:0048190; P:wing disc dorsal/ventral pattern formation; IGI:FlyBase. 
Interpro
 IPR017956; AT_hook_DNA-bd_motif.
 IPR007797; TF_AF4/FMR2. 
Pfam
 PF05110; AF-4 
SMART
 SM00384; AT_hook 
PROSITE
 PS00354; HMGI_Y 
PRINTS