UniProt Accession

 ST1A1_HUMAN; P50225; Q2NL71; Q86U58; Q92818; Q9BVU6; Q9UGG7 

Genbank Protein ID

 U09031; L19955; L10819; L19999; U26309; X84654; X78283; U71086; U54701; AJ007418; U52852; AB062428; BT007324; CR608214; AC020765; BC000923; BC110887; L15346 

Genbank Nucleotide ID

 AAA18613.1; AAA02935.1; AAA35562.1; AAA99892.1; AAA67895.1; CAA59147.1; CAA55089.1; AAB09597.1; AAC50480.1; CAA07495.1; AAC51816.1; BAB93491.1; AAP35988.1; AAH00923.1; AAI10888.1; AAA60595.1 

Protein Name

 Sulfotransferase 1A1 

Protein Synonyms/Alias

 ST1A1; Aryl sulfotransferase 1; HAST1/HAST2; Phenol sulfotransferase 1; Phenol-sulfating phenol sulfotransferase 1; P-PST 1; ST1A3; Thermostable phenol sulfotransferase; Ts-PST 

Gene Name

 SULT1A1 

Gene Synonyms/Alias

 STP; STP1; OK/SW-cl.88 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
85	RVPFLEFKAPGIPSG	ubiquitination	[1]
97	PSGMETLKDTPAPRL	ubiquitination	[1]
106	TPAPRLLKTHLPLAL	acetylation	[2]
122	PQTLLDQKVKVVYVA	ubiquitination	[1]
197	YLFYEDMKENPKREI	ubiquitination	[3]

Reference

 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] Lysine acetylation targets protein complexes and co-regulates major cellular functions.
 Choudhary C, Kumar C, Gnad F, Nielsen ML, Rehman M, Walther TC, Olsen JV, Mann M.
 Science. 2009 Aug 14;325(5942):834-40. [PMID: 19608861]
 [3] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473] 

Functional Description

 Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of catecholamines, phenolic drugs and neurotransmitters. Has also estrogen sulfotransferase activity. responsible for the sulfonation and activation of minoxidil. Is Mediates the metabolic activation of carcinogenic N- hydroxyarylamines to DNA binding products and could so participate as modulating factor of cancer risk. 

Sequence Annotation

 NP_BIND 48 53 PAPS.
 NP_BIND 227 232 PAPS.
 NP_BIND 255 259 PAPS.
 REGION 106 108 Substrate binding.
 ACT_SITE 108 108 Proton acceptor (By similarity).
 BINDING 130 130 PAPS.
 BINDING 138 138 PAPS.
 BINDING 193 193 PAPS.  

Keyword

 3D-structure; Alternative splicing; Catecholamine metabolism; Complete proteome; Cytoplasm; Direct protein sequencing; Lipid metabolism; Polymorphism; Reference proteome; Steroid metabolism; Transferase. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 295 AA 

Protein Sequence

Gene Ontology

 GO:0005829; C:cytosol; TAS:Reactome.
 GO:0004062; F:aryl sulfotransferase activity; IDA:UniProtKB.
 GO:0047894; F:flavonol 3-sulfotransferase activity; IDA:BHF-UCL.
 GO:0050294; F:steroid sulfotransferase activity; IDA:UniProtKB.
 GO:0050427; P:3'-phosphoadenosine 5'-phosphosulfate metabolic process; TAS:Reactome.
 GO:0009308; P:amine metabolic process; TAS:ProtInc.
 GO:0006584; P:catecholamine metabolic process; IEA:UniProtKB-KW.
 GO:0008210; P:estrogen metabolic process; IDA:UniProtKB.
 GO:0009812; P:flavonoid metabolic process; IDA:BHF-UCL.
 GO:0051923; P:sulfation; IDA:BHF-UCL.
 GO:0006805; P:xenobiotic metabolic process; IDA:UniProtKB. 

Interpro

 IPR027417; P-loop_NTPase.
 IPR000863; Sulfotransferase_dom. 

Pfam

 PF00685; Sulfotransfer_1 

SMART

  

PROSITE

  

PRINTS