CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-034418
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Interferon regulatory factor 7 
Protein Synonyms/Alias
 Interferon regulatory factor 7, isoform CRA_a 
Gene Name
 Irf7 
Gene Synonyms/Alias
 mCG_23297 
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
59EEDAQIFKAWAVARGubiquitination[1]
381KLEPWVCKAYLEGVQubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 425 AA 
Protein Sequence
MAEVRGVQRV LFGDWLLGEV SSGQYEGLQW LNEARTVFRV PWKHFGRRDL DEEDAQIFKA 60
WAVARGRWPP SGVNLPPPEA EAAERRERRG WKTNFRCALH STGRFILRQD NSGDPVDPHK 120
VYELSRELGS TVGPATENRE EVSLSNALPT QVLQYSHILE SESGADPVPP QAPGQEQDRV 180
YEEPYAAWQV EAVPSPRPQQ PALTERSLGF LDVTIMYKGR TVLQAVVGHP RCVFLYSPMA 240
PAVRTSEPQP VIFPSPAELP DQKQLHYTET LLQHVSPGLQ LELRGPSLWA LRMGKCKVYW 300
EVGSPMGTTG PSTPPQLLER NRHTPIFDFS TFFRELEEFR ARRRQGSPHY TIYLGFGQDL 360
SAGRPKEKTL ILVKLEPWVC KAYLEGVQRE GVSSLDSSSL GLCLSSTNSL YEDIEHFLMD 420
LGQWP 425 
Gene Ontology
 GO:0000975; F:regulatory region DNA binding; IEA:InterPro.
 GO:0003700; F:sequence-specific DNA binding transcription factor activity; IEA:InterPro.
 GO:0016064; P:immunoglobulin mediated immune response; IMP:MGI.
 GO:0060340; P:positive regulation of type I interferon-mediated signaling pathway; IMP:MGI.
 GO:0045351; P:type I interferon biosynthetic process; IMP:MGI. 
Interpro
 IPR019817; Interferon_reg_fac_CS.
 IPR001346; Interferon_reg_fact_DNA-bd_dom.
 IPR019471; Interferon_reg_factor-3.
 IPR017855; SMAD_dom-like.
 IPR008984; SMAD_FHA_domain.
 IPR011991; WHTH_DNA-bd_dom. 
Pfam
 PF00605; IRF
 PF10401; IRF-3 
SMART
 SM00348; IRF 
PROSITE
 PS00601; IRF_1
 PS51507; IRF_2 
PRINTS
 PR00267; INTFRNREGFCT.