| Tag | Content |
|---|
| CPLM ID | CPLM-002116 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Vitamin D-binding protein |
Protein Synonyms/Alias | DBP; VDB; Gc-globulin; Group-specific component |
Gene Name | Gc |
Gene Synonyms/Alias | Dbp |
Created Date | July 27, 2013 |
Organism | Rattus norvegicus (Rat) |
NCBI Taxa ID | 10116 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 238 | SRMSHLIKLAQKVPT | acetylation | [1] |
|
Reference | [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns. Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV. Cell Rep. 2012 Aug 30;2(2):419-31. [ PMID: 22902405] |
Functional Description | Multifunctional protein found in plasma, ascitic fluid, cerebrospinal fluid, and urine and on the surface of many cell types. In plasma, it carries the vitamin D sterols and prevents polymerization of actin by binding its monomers. DBP associates with membrane-bound immunoglobulin on the surface of B-lymphocytes and with IgG Fc receptor on the membranes of T-lymphocytes. |
Sequence Annotation | DOMAIN 17 208 Albumin 1.
DOMAIN 209 394 Albumin 2.
DOMAIN 395 476 Albumin 3.
CARBOHYD 288 288 N-linked (GlcNAc...) (Potential).
CARBOHYD 432 432 N-linked (GlcNAc...) (Potential).
DISULFID 29 75 By similarity.
DISULFID 74 83 By similarity.
DISULFID 96 112 By similarity.
DISULFID 111 122 By similarity.
DISULFID 145 190 By similarity.
DISULFID 189 198 By similarity.
DISULFID 220 266 By similarity.
DISULFID 265 273 By similarity.
DISULFID 286 300 By similarity.
DISULFID 299 311 By similarity.
DISULFID 335 376 By similarity.
DISULFID 375 384 By similarity.
DISULFID 407 453 By similarity.
DISULFID 452 462 By similarity. |
Keyword | Actin-binding; Complete proteome; Direct protein sequencing; Disulfide bond; Glycoprotein; Reference proteome; Repeat; Secreted; Signal; Transport; Vitamin D. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 476 AA |
Protein Sequence | MKRVLVLLLA LAFGHALERG RDYEKDKVCQ ELSTLGKDDF RSLSLILYSR KFPSSTFEQV 60
SQLVKEVVSL TEECCAEGAD PNCYDTRTSE LSIKSCESDA PFPVHPGTSE CCTKEGLERK 120
LCMAALSHQP QEFPAYVEPT NDEICEAFRK DPKGFADQFL FEYSSNYGQA PLPLLVGYTK 180
SYLSMVGSCC TSAKPTVCFL KERLQMKQLL LLTTMSNRVC SQYAAYGKEK SRMSHLIKLA 240
QKVPTANLED VLPLAEDLTE ILSRCCKSTS EDCMARELPE HTLKICGNLS KKNSKFEECC 300
YETTPMGIFM CSYFMPTAEP LQLPAIKLPT SKDLCGQSAT QAMDQYTFEL SRRTQVPEVF 360
LSKVLDTTLK TLRECCDTQD SVSCFSTQSP LMKRQLTSFI EKGQEMCADY SENTFTEYKK 420
KLAERLRTKM PNASPEELAD MVAKHSDFAS KCCSINSPPR YCSSQIDAEM RDILQS 476 |
Gene Ontology | |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |