Tag | Content |
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CPLM ID | CPLM-014487 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Phosphorylated adapter RNA export protein |
Protein Synonyms/Alias | 26 kDa resiniferatoxin-binding protein; RBP-26; RNA U small nuclear RNA export adapter protein; RTX-42; Resiniferatoxin-binding protein 2; RBP-2 |
Gene Name | Phax |
Gene Synonyms/Alias | Rnuxa |
Created Date | July 27, 2013 |
Organism | Rattus norvegicus (Rat) |
NCBI Taxa ID | 10116 |
Lysine Modification | Position | Peptide | Type | References |
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148 | TYNYLLAKKLAKKES | acetylation | [1] | 323 | RRTQLLGKKMKEAIK | acetylation | [1] |
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Reference | [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns. Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV. Cell Rep. 2012 Aug 30;2(2):419-31. [ PMID: 22902405] |
Functional Description | A phosphoprotein adapter involved in the XPO1-mediated U snRNA export from the nucleus. Bridge components required for U snRNA export, the cap binding complex (CBC)-bound snRNA on the one hand and the GTPase Ran in its active GTP-bound form together with the export receptor XPO1 on the other. Its phosphorylation in the nucleus is required for U snRNA export complex assembly and export, while its dephosphorylation in the cytoplasm causes export complex disassembly. It is recycled back to the nucleus via the importin alpha/beta heterodimeric import receptor. The directionality of nuclear export is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. Its compartmentalized phosphorylation cycle may also contribute to the directionality of export. Binds strongly to m7G-capped U1 and U5 small nuclear RNAs (snRNAs) in a sequence-unspecific manner and phosphorylation- independent manner. Plays also a role in the biogenesis of U3 small nucleolar RNA (snoRNA). Involved in the U3 snoRNA transport from nucleoplasm to Cajal bodies. Binds strongly to m7G-capped U3, U8 and U13 precursor snoRNAs and weakly to trimethylated (TMG)- capped U3, U8 and U13 snoRNAs. Binds also to telomerase RNA (By similarity). |
Sequence Annotation | REGION 2 320 Necessary for interaction with CBP80 (By REGION 219 319 Sufficient for poly U RNA-binding (By REGION 270 278 Necessary for poly U RNA-binding and MOTIF 71 74 Nuclear localization signal (By MOTIF 120 129 Nuclear export signal (By similarity). MOTIF 189 192 Nuclear localization signal (By MOD_RES 2 2 N-acetylalanine (By similarity). MOD_RES 14 14 Phosphoserine (By similarity). MOD_RES 287 287 Phosphothreonine (By similarity). MOD_RES 347 347 Phosphoserine (By similarity). |
Keyword | Acetylation; Complete proteome; Cytoplasm; Nucleus; Phosphoprotein; Protein transport; Reference proteome; RNA-binding; Transport. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 385 AA |
Protein Sequence | MALEAGDMEE GQLSDSDSDM TVVPSDRPLQ MAKVLGGGGA ACAPVSNYRT VKHVDSSEES 60 LDSDDDCSLW KRKRQKCHSP PPKPEPFPFG QSGQKPALNG GKKVNNIWGA VLQEQNQDAV 120 ATELGILGME GTIDRSRQSE TYNYLLAKKL AKKESQEYTK ELDKDLDEYM HGDKKPGSKE 180 EENGQGHLKR KRPVRDRLGN RVEMNYKGRY DITEEDSPEK VADEIAFRLQ EPKKDLIARV 240 VTILGNKKAI ELLMETAEVE QNGGLFIMNG SRRRTPGGVF LNLLKNTPSI SEEQIKDIFY 300 IENQKEYENK KAARKRRTQL LGKKMKEAIK SLNFQEDDDT SRETFASDTN EALASLDEAQ 360 EGPGETKLDA EDAIEVDHPQ DLDIF 385 |
Gene Ontology | |
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