| Tag | Content |
|---|
| CPLM ID | CPLM-013881 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Serine hydroxymethyltransferase |
Protein Synonyms/Alias | SHMT; Serine methylase |
Gene Name | glyA |
Gene Synonyms/Alias | TTHA1524 |
Created Date | July 27, 2013 |
Organism | Thermus thermophilus (strain HB8 / ATCC 27634 / DSM 579) |
NCBI Taxa ID | 300852 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 326 | RPKGLTGKEAEERLD | acetylation | [1] |
|
Reference | [1] Acetylome with structural mapping reveals the significance of lysine acetylation in Thermus thermophilus. Okanishi H, Kim K, Masui R, Kuramitsu S. J Proteome Res. 2013 Aug 1;. [ PMID: 23901841] |
Functional Description | Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity). |
Sequence Annotation | REGION 121 123 Substrate binding (By similarity).
BINDING 31 31 Pyridoxal phosphate (By similarity).
BINDING 51 51 Pyridoxal phosphate.
BINDING 53 53 Substrate (By similarity).
BINDING 60 60 Substrate (By similarity).
BINDING 61 61 Pyridoxal phosphate (By similarity).
BINDING 95 95 Pyridoxal phosphate (By similarity).
BINDING 117 117 Substrate; via carbonyl oxygen (By
BINDING 172 172 Pyridoxal phosphate.
BINDING 200 200 Pyridoxal phosphate.
BINDING 225 225 Pyridoxal phosphate.
BINDING 232 232 Pyridoxal phosphate (By similarity).
BINDING 258 258 Pyridoxal phosphate; via amide nitrogen
BINDING 358 358 Pyridoxal phosphate (By similarity).
MOD_RES 226 226 N6-(pyridoxal phosphate)lysine (By |
Keyword | 3D-structure; Amino-acid biosynthesis; Complete proteome; Cytoplasm; One-carbon metabolism; Pyridoxal phosphate; Reference proteome; Transferase. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 407 AA |
Protein Sequence | MVSTLKRDEA LFELIALEEK RQREGLELIA SENFVSKQVR EAVGSVLTNK YAEGYPGARY 60
YGGCEVIDRV ESLAIERAKA LFGAAWANVQ PHSGSQANMA VYMALMEPGD TLMGMDLAAG 120
GHLTHGSRVN FSGKLYKVVS YGVRPDTELI DLEEVRRLAL EHRPKVIVAG ASAYPRFWDF 180
KAFREIADEV GAYLVVDMAH FAGLVAAGLH PNPLPYAHVV TSTTHKTLRG PRGGLILSND 240
PELGKRIDKL IFPGIQGGPL EHVIAGKAVA FFEALQPEFK EYSRLVVENA KRLAEELARR 300
GYRIVTGGTD NHLFLVDLRP KGLTGKEAEE RLDAVGITVN KNAIPFDPKP PRVTSGIRIG 360
TPAITTRGFT PEEMPLVAEL IDRALLEGPS EALREEVRRL ALAHPMP 407 |
Gene Ontology | GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell. GO:0004372; F:glycine hydroxymethyltransferase activity; IEA:HAMAP. GO:0030170; F:pyridoxal phosphate binding; IEA:HAMAP. GO:0019264; P:glycine biosynthetic process from serine; IEA:HAMAP. GO:0035999; P:tetrahydrofolate interconversion; IEA:UniProtKB-UniPathway. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |