CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-013351
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Xin actin-binding repeat-containing protein 2 
Protein Synonyms/Alias
 Beta-xin; Cardiomyopathy-associated protein 3; Myogenic MEF2-activated Xin-related protein; Myomaxin; mXinbeta 
Gene Name
 Xirp2 
Gene Synonyms/Alias
 Cmya3; Xin2 
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
825EIQAGNVKSARWLFEubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023
Functional Description
 Protects actin filaments from depolymerization (By similarity). 
Sequence Annotation
 REPEAT 308 323 Xin 1.
 REPEAT 343 358 Xin 2.
 REPEAT 383 398 Xin 3.
 REPEAT 420 435 Xin 4.
 REPEAT 458 473 Xin 5.
 REPEAT 498 513 Xin 6.
 REPEAT 536 551 Xin 7.
 REPEAT 574 589 Xin 8.
 REPEAT 608 623 Xin 9.
 REPEAT 642 657 Xin 10.
 REPEAT 679 694 Xin 11.
 REPEAT 715 730 Xin 12.
 REPEAT 746 761 Xin 13.
 REPEAT 784 799 Xin 14.
 REPEAT 822 837 Xin 15.
 REPEAT 861 876 Xin 16.
 REPEAT 894 909 Xin 17.
 REPEAT 932 947 Xin 18.
 REPEAT 967 982 Xin 19.
 REPEAT 1006 1021 Xin 20.
 REPEAT 1042 1057 Xin 21.
 REPEAT 1079 1094 Xin 22.
 REPEAT 1117 1132 Xin 23.
 REPEAT 1154 1169 Xin 24.
 REPEAT 1188 1203 Xin 25.
 REPEAT 1219 1234 Xin 26.
 REPEAT 1256 1271 Xin 27.
 REPEAT 1291 1306 Xin 28.
 DOMAIN 3255 3315 LIM zinc-binding.  
Keyword
 Actin-binding; Alternative splicing; Cell junction; Coiled coil; Complete proteome; LIM domain; Metal-binding; Reference proteome; Repeat; Zinc. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 3784 AA 
Protein Sequence
MARYQAAVSR GDTRSFSANV MEESDVCTVP GGLAKMKRQF EKDKMTSTCN AFSEYQYRHE 60
SRAEQEAIHS SQEIIRRNEQ EVSKGHGTDV FKAEMMSHLE KHTEETKQAS QFHQYVQETV 120
IDSPEEEELP KVSTKILKEQ FEKSAQENFL RSDKETSPPA KCMKIENDIE ETLKPSSAVG 180
TSSSYTSTRQ RKETSTSSYS NHSLTSTTLA QDNGTPSGKM EEFPPPPPDV CQTPMDVTAF 240
SQSPEFPSPP RRLPMPKDLY SKQRNLYELN RLYRHIHPEL RKNLEKDYIS EVSEIVSSQI 300
NSGNALSADV QKARYVFENT NDSSQKDLNS ERENLEWDEI LKGEVQSIRW IFENQPLDSI 360
NHGSTDEGYT SKGIADQELI AGSDVKYTTW MFETQPIDAL GIPSAGTEGN TEKIPELARG 420
DVYTARWMFE TRPLDSMNKM HECQEETAST LTKDITGGDV KTVRYMFETQ QLDQLGQLHS 480
VDELNLLQLR SELKEIKGNV KRSIKCFETQ PLYVIRDGSG QMLEIKTVQR EDIEKGDVRT 540
ARWMFETQPL DTINKDITEI KVVRGISMEE NVKGGVSRAK WLFETQPLEK IKEESGEAVL 600
KTEAVIGTDV SKKCWMFETQ PLDILKDSPD TDSVSPEERI GGDVKTTKHL FETLPIEALK 660
DSPDIGKLQK ITASEEEKGD VKHQKWVFET QRLEDIREDK KEYTRTVRLE AVDRGHVKNY 720
THIFESNNLI KVDASHQIEV EGVTRGTVEL NKSLFETTPL YAIQDHLGKY HQVKTVQQEE 780
IVRGDVRSCR WLFETRPIDQ FDESLHKFQI IRGISAQEIQ AGNVKSARWL FETQPLDSIK 840
YFSNVEETDS KTEQSTDIVK GDVKTCKWLF ETQPMESLYE KASLMTNSED IHKGDVRTCM 900
WLFETQPLDA IKDDSEATVK LQTVKQEEIQ GGDVQTACFL FETENLDNIQ GDEGKENKPL 960
EMDIQSGDVS GMKFKFENQS LDSINCSSEN VLSKIKTLKA EDIQKGNVLK CRWLFENQPI 1020
DMIKESQECD GLVKTVTDVQ GGDVRKGCFI FETFSLDEIK DESDGISMRE TNLGEIIKGD 1080
VKSYKMLFET QPLYAIQDHE GFYHEVTTVK KEETIHGDVR GTRWLFETKP LDSIHESEDV 1140
YVIKSVTQED IQKGDVSSVR YRFETQPLDM ISDKSHNIVP TVDYIQGGNV QMNKQLFESE 1200
GGNKKNYVRT VSVNEIQKGN VKTSTWLFET HRIDELGEES RYENIKTVTQ EDVQKGDVKQ 1260
AVWLFENQTL DSINELDEND TKMTKEEIPP SDVKTTTWLF ETTPIHEFNK TRVEKEEIIG 1320
KSIKETLEDL YSQRVVEAPG IIIEADEVGD VRMAKYKLMN QTTPEIQKEE VIRADLGNIM 1380
MNLLSQRDCT KKEIFVSEEE KGNVNFTKTQ LLNRSMEFHA EKEEIVRGDV KQAIQKLFSE 1440
ERRAKKGILI QEDEKGDINM TIYCLLHENA GDKTEREDIL GGDVRRTIHN LLSSASNGKI 1500
SERTKIDASE RGNVQFFTTC IETGALDYLK QLQTGSNEST LTASKQEGEE EIIGGDVEGT 1560
KFLLKKRQSS FERTVSETDI IPGDVRHTVK VFMTEPQSSS YKTVKDEIIK GDLKSTLNSL 1620
NQAMNQKTVA KAEEIVKDDR LAILKSLKES GDRQKEPKQS GGMSRDIGQA IECLERATNT 1680
RTEILKKELI LDDLKTSLRS LKEEQCGFKE VDKQGIVKDV LPGMLGFSER PKIGIHPAAV 1740
QRDKKSLLQP VPGPFEPAIK QQAGPGTLDE TTQKPCLRSL IEERTEANLP KAPKGTVKIV 1800
IDREQNNDAL EKSLRKMSNS EHRAMKNVLD MSDRMGIWTE SKEYLCSDDH MSKHLSATMS 1860
IKESLKSKES ENMREAKDDV ISSTQSVDKT FRKQQTQTCE LGNDQKSRFQ DSYGKNQKNI 1920
QNIEITRDFQ KQALLSQEKQ YSNKEMKKNE ASLQPLPVGK EVHSVPGVTV SGKNHKRIQA 1980
TDKRQKTDVC LESQDFLMKT NTSKELKMAM ERSFNPINLH PECGIKENED SLPPPSPPPL 2040
PPSNASSEIE FPLPPPPPLM LLPGKNESPP SSPTEKTRTE FESLSTLPLP PPPVDEKAEQ 2100
ECLSTTLPPP PPPTPCQPGH LLPSSVLGHH REAFLQQFSQ KEALGVHLPH SQAKILTGKS 2160
PPPTLPKPKL PKRIKDKMNQ YSSSGELERS LSDVEIKATL SKDQKRSMVT MSSEHRETKQ 2220
DVFGKGLVGR KQLPVDSANS LSQTVPEIPA PKEKQTAPLV KSHSFPSGSE QQSPKPYMRK 2280
FKTPLMIAEE KYRQQREELE KQRQESSSHN VIKTETQHQS LSEKEEEIEL QKATEAISTP 2340
RKESDFPRAR PNLDSESRAV IAGECSESQL ATASTLTVAT ERLQHVLAAS EDELTLRQEG 2400
IQNSSDASQS KLACETSQSH KECKAQQTFE QHVKRLPFPQ TKPSSPSFKV KTIKLSTLDH 2460
TGTETDLSSK HHTKQSEVDI QTSTEQTDKE IKKTQASIQC DDKPSVPEKY FQLPKTEKRV 2520
TIQMPKEYAE KSHKSKLQTV PKKQGIFGEF DRGNVLGREG KNQDSSVSCS KEDRLIDERK 2580
QEHLQNQRVP RSVQQKVINE RLDSQMQNFQ QTEIQTSRST IECEEFSQSY NATQEKTCLK 2640
DKGKQQGQVT SNTEESKQEL RQNQSAFSSV KDSQHDDGKC TINILEFLRK REELQQILSR 2700
VKQFEAESSK SGLKTFQILL NIVPVWLISE EKREYGVRVA MENNFEKVKE EITHIKTQAE 2760
EMLLQCEHVI QTAMMASQTG KQRDKPTNLN EMPLNVSNVN LSSSKCTEQK ESKTVEEKLT 2820
HRQVTTHPEA ATRNPVKPYQ EAKGEDGKMA PPSLKTRPPS PTFITIESTA RRAETSTKSE 2880
LSQSPKNNRC IEPPPRRPVE HASGLPRSRT PPSPPRSRSE QLVRLKDTTA RLAKGTIPCS 2940
PGTPVPIVEK RSEVVMSPAT LRRQIKIESR GGDSPPTITI PVSVNHVVSG SFRESVDAQE 3000
AVKKTEKTET YVHKDKMNSV NRAMPETESY DAVEIIRKVE GPHLSEHTER FEATNQTVQR 3060
AERFLNGHEN EINRWFREFE NDPVFRAKTE RGAYANGEIN HNMKQESHTF CKEEFGLASS 3120
ETANFTGFSY RHPKVPAMQP RVHSEARSLN EHFSSVDAFD SQIVGSKVAT SSSRSTEAGR 3180
SGFDFKHAPP TYEDVISGHI LDVADSPTNL RRNFQKTWQE SERVFQRVGY ETSDAHATEM 3240
SRAFQEESAF LSDKEICIIC QKTVYPMECL IADKQNFHKS CFRCHHCSSK LSLGNYASLH 3300
GRIYCKPHFK QLFKSKGNYD EGFGHKQHKD RWNCKNQSSL VDFIPSGEPD AHENPTADTL 3360
LLGDLTTHPD ACNSKRQDND LRKWGDRGKL KIVWPPCQEM PKKNSPPEEE FKVNKAKWPP 3420
EVTIPVPSDF KRESLTEHVK TLESQGQEQD SVPDLQPCKH VCQKEDITGI KEIKGYEERK 3480
DEKEAKDTLK DAEGLRSKRK SGMEFNDHNA HAQSDGKEKN ALVNEADSAD VLQVANTDDE 3540
GGPENHRENF NNNNNNSVAV SSLNNGRQKI SISERPRLLQ AVSEANYYTS EYQIKNFNNA 3600
SKISELLGIF ESQKLSSKKV LALALERTAD RGTAGSPLQL VLEPGLQQGF SVKGENLAAS 3660
PDVSPLHIKG NHENNKNVHL FFSNTVKITS FSKKHNILGC DLMDSVDQLK NMSCLYLREL 3720
GKNVKCWHGE TAGAARHGGK MCFDAQSQGS AAKPVFPSMQ CQAQHLTVEE QIKRDRCYSD 3780
SEAD 3784 
Gene Ontology
 GO:0030054; C:cell junction; IEA:UniProtKB-SubCell.
 GO:0030018; C:Z disc; IDA:MGI.
 GO:0051393; F:alpha-actinin binding; IDA:MGI.
 GO:0008270; F:zinc ion binding; IEA:InterPro.
 GO:0030036; P:actin cytoskeleton organization; IEA:InterPro.
 GO:0055008; P:cardiac muscle tissue morphogenesis; IMP:MGI.
 GO:0045216; P:cell-cell junction organization; IMP:MGI.
 GO:0003281; P:ventricular septum development; IMP:MGI. 
Interpro
 IPR012510; Actin-binding_Xin_repeat.
 IPR001781; Znf_LIM. 
Pfam
 PF00412; LIM
 PF08043; Xin 
SMART
 SM00132; LIM 
PROSITE
 PS00478; LIM_DOMAIN_1
 PS50023; LIM_DOMAIN_2
 PS51389; XIN 
PRINTS