UniProt Accession

 IF5A_DROME; Q9GU68; Q2MGM4; Q9NDH0; Q9W1C0 

Genbank Protein ID

 AF159443; AF187730; AE013599; AY071396 

Genbank Nucleotide ID

 AAF80375.1; AAG17032.1; AAF47151.1; AAL49018.1 

Protein Name

 Eukaryotic translation initiation factor 5A 

Protein Synonyms/Alias

 eIF-5A 

Gene Name

 eIF-5A 

Gene Synonyms/Alias

 CG3186 

Created Date

 July 27, 2013 

Organism

 Drosophila melanogaster (Fruit fly) 

NCBI Taxa ID

 7227 

Lysine Modification

Position	Peptide	Type	References
28	MQCSALRKNGFVMLK	acetylation	[1]
35	KNGFVMLKSRPCKIV	acetylation	[1]
48	IVEMSTSKTGKHGHA	acetylation	[1]

Reference

 [1] Proteome-wide mapping of the Drosophila acetylome demonstrates a high degree of conservation of lysine acetylation.
 Weinert BT, Wagner SA, Horn H, Henriksen P, Liu WR, Olsen JV, Jensen LJ, Choudhary C.
 Sci Signal. 2011 Jul 26;4(183):ra48. [PMID: 21791702] 

Functional Description

 mRNA-binding protein involved in translation elongation. Has an important function at the level of mRNA turnover, probably acting downstream of decapping. Involved in actin dynamics and cell cycle progression, mRNA decay and probably in a pathway involved in stress response and maintenance of cell wall integrity. Functions as a regulator of apoptosis. 

Sequence Annotation

 MOD_RES 51 51 Hypusine (By similarity).  

Keyword

 Complete proteome; Cytoplasm; Elongation factor; Hypusine; Protein biosynthesis; Reference proteome; RNA-binding. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 159 AA 

Protein Sequence

Gene Ontology

 GO:0005829; C:cytosol; NAS:UniProtKB.
 GO:0043022; F:ribosome binding; IEA:InterPro.
 GO:0003746; F:translation elongation factor activity; IMP:UniProtKB.
 GO:0003743; F:translation initiation factor activity; NAS:UniProtKB.
 GO:0032504; P:multicellular organism reproduction; IEP:FlyBase.
 GO:0008612; P:peptidyl-lysine modification to hypusine; IEA:InterPro.
 GO:0045901; P:positive regulation of translational elongation; IMP:UniProtKB.
 GO:0045905; P:positive regulation of translational termination; IEA:InterPro.
 GO:0042981; P:regulation of apoptotic process; IMP:UniProtKB.
 GO:0035071; P:salivary gland cell autophagic cell death; IEP:FlyBase.
 GO:0006452; P:translational frameshifting; IEA:InterPro.
 GO:0035220; P:wing disc development; IGI:FlyBase. 

Interpro

 IPR012340; NA-bd_OB-fold.
 IPR014722; Rib_L2_dom2.
 IPR019769; Trans_elong_IF5A_hypusine_site.
 IPR001884; Transl_elong_IF5A.
 IPR020189; Transl_elong_IF5A_C.
 IPR008991; Translation_prot_SH3-like. 

Pfam

 PF01287; eIF-5a 

SMART

  

PROSITE

 PS00302; IF5A_HYPUSINE 

PRINTS