UniProt Accession

 GRTP1_HUMAN; Q5TC63; Q2M232; Q5TC64; Q66K26; Q6P659; Q8N528; Q9H695 

Genbank Protein ID

 AL136221; AL136221; BC033071; BC062461; BC080640; BC112123; BC112125; AK026127 

Genbank Nucleotide ID

 CAI13799.2; CAI13800.2; AAH33071.2; AAH62461.1; AAH80640.1; AAI12124.1; AAI12126.1; BAB15368.1 

Protein Name

 Growth hormone-regulated TBC protein 1 

Protein Synonyms/Alias

 TBC1 domain family member 6 

Gene Name

 GRTP1 

Gene Synonyms/Alias

 TBC1D6 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
124	RTFPDNVKFRKTTDP	ubiquitination	[1, 2]
323	LSMATVAKLRESCRA	ubiquitination	[1, 2, 3]

Reference

 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [2] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789]
 [3] Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass.
 Povlsen LK, Beli P, Wagner SA, Poulsen SL, Sylvestersen KB, Poulsen JW, Nielsen ML, Bekker-Jensen S, Mailand N, Choudhary C.
 Nat Cell Biol. 2012 Oct;14(10):1089-98. [PMID: 23000965] 

Functional Description

 May act as a GTPase-activating protein for Rab family protein(s). 

Sequence Annotation

 DOMAIN 68 258 Rab-GAP TBC.  

Keyword

 Alternative splicing; Complete proteome; Direct protein sequencing; GTPase activation; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 336 AA 

Protein Sequence

Gene Ontology

 GO:0005622; C:intracellular; IEA:InterPro.
 GO:0005097; F:Rab GTPase activator activity; IEA:InterPro.
 GO:0032851; P:positive regulation of Rab GTPase activity; IEA:GOC. 

Interpro

 IPR000195; Rab-GTPase-TBC_dom. 

Pfam

 PF00566; RabGAP-TBC 

SMART

 SM00164; TBC 

PROSITE

 PS50086; TBC_RABGAP 

PRINTS