CPLM-015621

Genbank Nucleotide ID

Cyclic AMP-responsive element-binding protein 3-like protein 2

Protein Synonyms/Alias

cAMP-responsive element-binding protein 3-like protein 2; BBF2 human homolog on chromosome 7; Processed cyclic AMP-responsive element-binding protein 3-like protein 2

Homo sapiens (Human)

Position	Peptide	Type	References
178	QTIIPKIKLEPHEVD	ubiquitination	[1]
325	YMDSLEKKVESCSTE	ubiquitination	[1]
338	TENLELRKKVEVLEN	ubiquitination	[1, 2]
339	ENLELRKKVEVLENT	ubiquitination	[1]
356	TLLQQLQKLQTLVMG	ubiquitination	[3]
364	LQTLVMGKVSRTCKL	ubiquitination	[1, 2, 3, 4]

[1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
[2] Global identification of modular cullin-RING ligase substrates.
Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094]
[3] Systematic and quantitative assessment of the ubiquitin-modified proteome.
Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
[4] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]

Functional Description

Transcriptional activator which is processed and activated during endoplasmic reticulum stress late phase. Binds to the cAMP response element (CRE) and activates transcription through CRE. Regulates the transcription of unfolded protein response target genes, preventing accumulation of unfolded proteins in damaged neurons. Also regulates the expression of SEC23A, accelerating protein trafficking from the ER to the Golgi thereby playing a key role in chondrocyte differentiation and formation of epiphyseal cartilage (By similarity).

DOMAIN 294 357 bZIP.
REGION 296 325 Basic motif (By similarity).
REGION 336 357 Leucine-zipper (By similarity).
MOD_RES 191 191 Phosphoserine.
CARBOHYD 480 480 N-linked (GlcNAc...) (Potential).
CARBOHYD 504 504 N-linked (GlcNAc...) (Potential).
CARBOHYD 517 517 N-linked (GlcNAc...) (Potential).

Activator; Alternative splicing; Chromosomal rearrangement; Complete proteome; DNA-binding; Endoplasmic reticulum; Glycoprotein; Membrane; Nucleus; Phosphoprotein; Polymorphism; Proto-oncogene; Reference proteome; Signal-anchor; Transcription; Transcription regulation; Transmembrane; Transmembrane helix; Unfolded protein response.

UniProt (SWISSPROT/TrEMBL); GenBank; EMBL

GO:0005783; C:endoplasmic reticulum; IDA:UniProtKB.
GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
GO:0005634; C:nucleus; IDA:UniProtKB.
GO:0035497; F:cAMP response element binding; IMP:UniProtKB.
GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
GO:0003700; F:sequence-specific DNA binding transcription factor activity; IEA:InterPro.
GO:0002062; P:chondrocyte differentiation; ISS:UniProtKB.
GO:0006888; P:ER to Golgi vesicle-mediated transport; IEA:Compara.
GO:0045893; P:positive regulation of transcription, DNA-dependent; IDA:UniProtKB.
GO:0034976; P:response to endoplasmic reticulum stress; IEP:UniProtKB.
GO:0006986; P:response to unfolded protein; IEA:UniProtKB-KW.
GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.

IPR004827; bZIP.
IPR008917; Euk_TF_DNA-bd.

PS50217; BZIP
PS00036; BZIP_BASIC