UniProt Accession

 E5KP25_HUMAN; E5KP25 

Genbank Protein ID

 AL359540; HQ205466; HQ205468; HQ205469; HQ205470; HQ205472; HQ205473; HQ205474; HQ205475; HQ205476; HQ205477; HQ205479; HQ205480; HQ205481; HQ205482; HQ205483; HQ205484; HQ205485; HQ205486; HQ205487; HQ205488; HQ205489; HQ205490; HQ205491; HQ205492; HQ205493; HQ205494; HQ205495; HQ205496; HQ205497; HQ205498; HQ205499; HQ205500; HQ205501; HQ205502; HQ205503; HQ205505 

Genbank Nucleotide ID

 ADP90936.1; ADP90946.1; ADP90951.1; ADP90956.1; ADP90966.1; ADP90971.1; ADP90976.1; ADP90981.1; ADP90986.1; ADP90991.1; ADP91001.1; ADP91006.1; ADP91011.1; ADP91016.1; ADP91021.1; ADP91026.1; ADP91031.1; ADP91036.1; ADP91041.1; ADP91046.1; ADP91051.1; ADP91056.1; ADP91061.1; ADP91066.1; ADP91071.1; ADP91076.1; ADP91081.1; ADP91086.1; ADP91091.1; ADP91096.1; ADP91101.1; ADP91106.1; ADP91111.1; ADP91116.1; ADP91121.1; ADP91131.1 

Protein Name

 A/G-specific adenine DNA glycosylase 

Protein Synonyms/Alias

  

Gene Name

 MUTYH 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
28	AVGSGHRKQAASQEG	ubiquitination	[1]
108	LSWYDQEKRDLPWRR	ubiquitination	[2, 3]
192	RLQEGARKVVEELGG	ubiquitination	[2]
418	PSEQLQRKALLQELQ	ubiquitination	[2]
509	PGTCMGSKRSQVSSP	ubiquitination	[2]

Reference

 [1] Proteome-wide identification of ubiquitylation sites by conjugation of engineered lysine-less ubiquitin.
 Oshikawa K, Matsumoto M, Oyamada K, Nakayama KI.
 J Proteome Res. 2012 Feb 3;11(2):796-807. [PMID: 22053931]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [3] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302] 

Functional Description

  

Sequence Annotation

  

Keyword

 Complete proteome; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 549 AA 

Protein Sequence

Gene Ontology

 GO:0005634; C:nucleus; IDA:HPA.
 GO:0051539; F:4 iron, 4 sulfur cluster binding; IEA:InterPro.
 GO:0004519; F:endonuclease activity; IEA:InterPro.
 GO:0006284; P:base-excision repair; IEA:InterPro. 

Interpro

 IPR011257; DNA_glycosylase.
 IPR004036; Endonuclease-III_CS2.
 IPR004035; Endouclease-III_FeS-bd_BS.
 IPR003651; Endouclease3_FeS-loop_motif.
 IPR003265; HhH-GPD_domain.
 IPR023170; HTH_base_excis_C.
 IPR000086; NUDIX_hydrolase_dom.
 IPR015797; NUDIX_hydrolase_dom-like. 

Pfam

 PF00730; HhH-GPD 

SMART

 SM00478; ENDO3c
 SM00525; FES 

PROSITE

 PS00764; ENDONUCLEASE_III_1
 PS01155; ENDONUCLEASE_III_2
 PS51462; NUDIX 

PRINTS