UniProt Accession

 TNNT2_RAT; P50753 

Genbank Protein ID

 M26051; M26052; M80829 

Genbank Nucleotide ID

 AAA42296.1; AAA42297.1; AAB07676.1 

Protein Name

 Troponin T, cardiac muscle 

Protein Synonyms/Alias

 TnTc; Cardiac muscle troponin T; cTnT 

Gene Name

 Tnnt2 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Rattus norvegicus (Rat) 

NCBI Taxa ID

 10116 

Lysine Modification

Position	Peptide	Type	References
202	HFGGYIQKAQTERKS	acetylation	[1]

Reference

 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 

Functional Description

 Troponin T is the tropomyosin-binding subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity. 

Sequence Annotation

 MOD_RES 2 2 N-acetylserine (By similarity).
 MOD_RES 2 2 Phosphoserine; by CK2 (By similarity).
 MOD_RES 205 205 Phosphothreonine; by PKC/PRKCA (By
 MOD_RES 209 209 Phosphoserine; by PKC/PRKCA (By
 MOD_RES 214 214 Phosphothreonine; by PKC/PRKCA and RAF1
 MOD_RES 295 295 Phosphothreonine; by PKC/PRKCA (By  

Keyword

 Acetylation; Alternative splicing; Complete proteome; Muscle protein; Phosphoprotein; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 299 AA 

Protein Sequence

Gene Ontology

 GO:0005861; C:troponin complex; IDA:RGD.
 GO:0003779; F:actin binding; ISS:UniProtKB.
 GO:0030674; F:protein binding, bridging; IDA:RGD.
 GO:0005523; F:tropomyosin binding; ISS:UniProtKB.
 GO:0030172; F:troponin C binding; ISS:UniProtKB.
 GO:0051764; P:actin crosslink formation; IDA:RGD.
 GO:0060048; P:cardiac muscle contraction; IDA:RGD.
 GO:0030049; P:muscle filament sliding; ISS:UniProtKB.
 GO:0032780; P:negative regulation of ATPase activity; ISS:UniProtKB.
 GO:0032781; P:positive regulation of ATPase activity; ISS:UniProtKB.
 GO:0051291; P:protein heterooligomerization; IPI:RGD.
 GO:0008016; P:regulation of heart contraction; ISS:UniProtKB.
 GO:0032972; P:regulation of muscle filament sliding speed; IMP:BHF-UCL.
 GO:0051592; P:response to calcium ion; ISS:UniProtKB.
 GO:0055010; P:ventricular cardiac muscle tissue morphogenesis; ISS:UniProtKB. 

Interpro

 IPR001978; Troponin. 

Pfam

 PF00992; Troponin 

SMART

  

PROSITE

  

PRINTS