UniProt Accession

 TF2B_YEAST; P29055; D6W488; E9P939 

Genbank Protein ID

 M81380; U51033; AY693232; BK006949 

Genbank Nucleotide ID

 AAA35126.1; AAB68135.1; AAT93251.1; DAA11504.1 

Protein Name

 Transcription initiation factor IIB 

Protein Synonyms/Alias

 General transcription factor TFIIB; Transcription factor E 

Gene Name

 SUA7 

Gene Synonyms/Alias

 YPR086W; P9513.4 

Created Date

 July 27, 2013 

Organism

 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 

NCBI Taxa ID

 559292 

Lysine Modification

Position	Peptide	Type	References
98	NLSTRIGKGETTDMR	ubiquitination	[1]
344	DNLPGVEKK******	acetylation	[2]

Reference

 [1] Global analysis of phosphorylation and ubiquitylation cross-talk in protein degradation.
 Swaney DL, Beltrao P, Starita L, Guo A, Rush J, Fields S, Krogan NJ, Villén J.
 Nat Methods. 2013 Jul;10(7):676-82. [PMID: 23749301]
 [2] Proteome-wide analysis of lysine acetylation suggests its broad regulatory scope in Saccharomyces cerevisiae.
 Henriksen P, Wagner SA, Weinert BT, Sharma S, Bacinskaja G, Rehman M, Juffer AH, Walther TC, Lisby M, Choudhary C.
 Mol Cell Proteomics. 2012 Nov;11(11):1510-22. [PMID: 22865919] 

Functional Description

 General factor that plays a major role in the activation of eukaryotic genes transcribed by RNA polymerase II. 

Sequence Annotation

 REPEAT 136 212 1.
 REPEAT 242 318 2.
 ZN_FING 20 53 TFIIB-type.
 METAL 24 24 Zinc (By similarity).
 METAL 27 27 Zinc (By similarity).
 METAL 45 45 Zinc (By similarity).
 METAL 48 48 Zinc (By similarity).  

Keyword

 3D-structure; Complete proteome; Metal-binding; Nucleus; Reference proteome; Repeat; Transcription; Transcription regulation; Zinc; Zinc-finger. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 345 AA 

Protein Sequence

Gene Ontology

 GO:0005634; C:nucleus; IDA:SGD.
 GO:0001139; F:core RNA polymerase II recruiting transcription factor activity; IMP:SGD.
 GO:0000993; F:RNA polymerase II core binding; IDA:SGD.
 GO:0017025; F:TBP-class protein binding; IDA:SGD.
 GO:0001129; F:TBP-class protein binding RNA polymerase II transcription factor activity involved in preinitiation complex assembly; IMP:SGD.
 GO:0008270; F:zinc ion binding; IEA:InterPro.
 GO:2000679; P:positive regulation of transcription regulatory region DNA binding; IDA:SGD.
 GO:0001113; P:transcriptional open complex formation at RNA polymerase II promoter; IMP:SGD.
 GO:0001174; P:transcriptional start site selection at RNA polymerase II promoter; IMP:SGD. 

Interpro

 IPR013763; Cyclin-like.
 IPR000812; TFIIB.
 IPR023486; TFIIB_CS.
 IPR013150; TFIIB_cyclin.
 IPR013137; Znf_TFIIB. 

Pfam

 PF08271; TF_Zn_Ribbon
 PF00382; TFIIB 

SMART

 SM00385; CYCLIN 

PROSITE

 PS00782; TFIIB
 PS51134; ZF_TFIIB 

PRINTS

 PR00685; TIFACTORIIB.