CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-017620
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Cytoplasmic dynein 2 heavy chain 1 
Protein Synonyms/Alias
 Cytoplasmic dynein 2 heavy chain; Dynein cytoplasmic heavy chain 2; Dynein heavy chain 11; hDHC11; Dynein heavy chain isotype 1B 
Gene Name
 DYNC2H1 
Gene Synonyms/Alias
 DHC1B; DHC2; DNCH2; DYH1B; KIAA1997 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
160DTNLTKLKFKEDDTRubiquitination[1]
398IIAPAEQKIAGKLKNubiquitination[1]
660SKAGSGGKSQITWDNubiquitination[2]
669QITWDNPKELEGYIQubiquitination[1, 2]
1348NLNHIQRKWVYLEPIubiquitination[1]
1733RIFVGLVKCGAWGCFubiquitination[2]
2004CKTGKVVKQYTMNPKubiquitination[2]
3223AAPESLRKTCLEEWTubiquitination[1]
3436LLQQEEDKKIQLAKLubiquitination[1]
3437LQQEEDKKIQLAKLEubiquitination[1]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661] 
Functional Description
 May function as a motor for intraflagellar retrograde transport. Functions in cilia biogenesis. May play a role in transport between endoplasmic reticulum and Golgi or organization of the Golgi in cells (By similarity). 
Sequence Annotation
 NP_BIND 145 152 ATP (Potential).
 NP_BIND 1689 1696 ATP (Potential).
 NP_BIND 1979 1986 ATP (Potential).
 NP_BIND 2291 2298 ATP (Potential).
 NP_BIND 2655 2662 ATP (Potential).
 REGION 1 1650 Stem (By similarity).
 REGION 1651 1875 AAA 1 (By similarity).
 REGION 1938 2161 AAA 2 (By similarity).
 REGION 2251 2505 AAA 3 (By similarity).
 REGION 2617 2863 AAA 4 (By similarity).
 REGION 2881 3169 Stalk (By similarity).
 REGION 3244 3473 AAA 5 (By similarity).
 REGION 3690 3905 AAA 6 (By similarity).  
Keyword
 Alternative splicing; ATP-binding; Cell membrane; Cell projection; Ciliopathy; Cilium; Cilium biogenesis/degradation; Coiled coil; Complete proteome; Cytoplasm; Cytoskeleton; Developmental protein; Disease mutation; Dynein; Membrane; Microtubule; Motor protein; Nucleotide-binding; Polymorphism; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 4307 AA 
Protein Sequence
MANGTADVRK LFIFTTTQNY FGLMSELWDQ PLLCNCLEIN NFLDDGNQML LRVQRSDAGI 60
SFSNTIEFGD TKDKVLVFFK LRPEVITDEN LHDNILVSSM LESPISSLYQ AVRQVFAPML 120
LKDQEWSRNF DPKLQNLLSE LEAGLGIVLR RSDTNLTKLK FKEDDTRGIL TPSDEFQFWI 180
EQAHRGNKQI SKERANYFKE LFETIAREFY NLDSLSLLEV VDLVETTQDV VDDVWRQTEH 240
DHYPESRMLH LLDIIGGSFG RFVQKKLGTL NLWEDPYYLV KESLKAGISI CEQWVIVCNH 300
LTGQVWQRYV PHPWKNEKYF PETLDKLGKR LEEVLAIRTI HEKFLYFLPA SEEKIICLTR 360
VFEPFTGLNP VQYNPYTEPL WKAAVSQYEK IIAPAEQKIA GKLKNYISEI QDSPQQLLQA 420
FLKYKELVKR PTISKELMLE RETLLARLVD SIKDFRLDFE NRCRGIPGDA SGPLSGKNLS 480
EVVNSIVWVR QLELKVDDTI KIAEALLSDL PGFRCFHQSA KDLLDQLKLY EQEQFDDWSR 540
DIQSGLSDSR SGLCIEASSR IMELDSNDGL LKVHYSDRLV ILLREVRQLS ALGFVIPAKI 600
QQVANIAQKF CKQAIILKQV AHFYNSIDQQ MIQSQRPMML QSALAFEQII KNSKAGSGGK 660
SQITWDNPKE LEGYIQKLQN AAERLATENR KLRKWHTTFC EKVVVLMNID LLRQQQRWKD 720
GLQELRTGLA TVEAQGFQAS DMHAWKQHWN HQLYKALEHQ YQMGLEALNE NLPEINIDLT 780
YKQGRLQFRP PFEEIRAKYY REMKRFIGIP NQFKGVGEAG DESIFSIMID RNASGFLTIF 840
SKAEDLFRRL SAVLHQHKEW IVIGQVDMEA LVEKHLFTVH DWEKNFKALK IKGKEVERLP 900
SAVKVDCLNI NCNPVKTVID DLIQKLFDLL VLSLKKSIQA HLHEIDTFVT EAMEVLTIMP 960
QSVEEIGDAN LQYSKLQERK PEILPLFQEA EDKNRLLRTV AGGGLETISN LKAKWDKFEL 1020
MMESHQLMIK DQIEVMKGNV KSRLQIYYQE LEKFKARWDQ LKPGDDVIET GQHNTLDKSA 1080
KLIKEKKIEF DDLEVTRKKL VDDCHHFRLE EPNFSLASSI SKDIESCAQI WAFYEEFQQG 1140
FQEMANEDWI TFRTKTYLFE EFLMNWHDRL RKVEEHSVMT VKLQSEVDKY KIVIPILKYV 1200
RGEHLSPDHW LDLFRLLGLP RGTSLEKLLF GDLLRVADTI VAKAADLKDL NSRAQGEVTI 1260
REALRELDLW GVGAVFTLID YEDSQSRTMK LIKDWKDIVN QVGDNRCLLQ SLKDSPYYKG 1320
FEDKVSIWER KLAELDEYLQ NLNHIQRKWV YLEPIFGRGA LPKEQTRFNR VDEDFRSIMT 1380
DIKKDNRVTT LTTHAGIRNS LLTILDQLQR CQKSLNEFLE EKRSAFPRFY FIGDDDLLEI 1440
LGQSTNPSVI QSHLKKLFAG INSVCFDEKS KHITAMKSLE GEVVPFKNKV PLSNNVETWL 1500
NDLALEMKKT LEQLLKECVT TGRSSQGAVD PSLFPSQILC LAEQIKFTED VENAIKDHSL 1560
HQIETQLVNK LEQYTNIDTS SEDPGNTESG ILELKLKALI LDIIHNIDVV KQLNQIQVHT 1620
TEDWAWKKQL RFYMKSDHTC CVQMVDSEFQ YTYEYQGNAS KLVYTPLTDK CYLTLTQAMK 1680
MGLGGNPYGP AGTGKTESVK ALGGLLGRQV LVFNCDEGID VKSMGRIFVG LVKCGAWGCF 1740
DEFNRLEESV LSAVSMQIQT IQDALKNHRT VCELLGKEVE VNSNSGIFIT MNPAGKGYGG 1800
RQKLPDNLKQ LFRPVAMSHP DNELIAEVIL YSEGFKDAKV LSRKLVAIFN LSRELLTPQQ 1860
HYDWGLRALK TVLRGSGNLL RQLNKSGTTQ NANESHIVVQ ALRLNTMSKF TFTDCTRFDA 1920
LIKDVFPGIE LKEVEYDELS AALKQVFEEA NYEIIPNQIK KALELYEQLC QRMGVVIVGP 1980
SGAGKSTLWR MLRAALCKTG KVVKQYTMNP KAMPRYQLLG HIDMDTREWS DGVLTNSARQ 2040
VVREPQDVSS WIICDGDIDP EWIESLNSVL DDNRLLTMPS GERIQFGPNV NFVFETHDLS 2100
CASPATISRM GMIFLSDEET DLNSLIKSWL RNQPAEYRNN LENWIGDYFE KALQWVLKQN 2160
DYVVETSLVG TVMNGLSHLH GCRDHDEFII NLIRGLGGNL NMKSRLEFTK EVFHWARESP 2220
PDFHKPMDTY YDSTRGRLAT YVLKKPEDLT ADDFSNGLTL PVIQTPDMQR GLDYFKPWLS 2280
SDTKQPFILV GPEGCGKGML LRYAFSQLRS TQIATVHCSA QTTSRHLLQK LSQTCMVIST 2340
NTGRVYRPKD CERLVLYLKD INLPKLDKWG TSTLVAFLQQ VLTYQGFYDE NLEWVGLENI 2400
QIVASMSAGG RLGRHKLTTR FTSIVRLCSI DYPEREQLQT IYGAYLEPVL HKNLKNHSIW 2460
GSSSKIYLLA GSMVQVYEQV RAKFTVDDYS HYFFTPCILT QWVLGLFRYD LEGGSSNHPL 2520
DYVLEIVAYE ARRLFRDKIV GAKELHLFDI ILTSVFQGDW GSDILDNMSD SFYVTWGARH 2580
NSGARAAPGQ PLPPHGKPLG KLNSTDLKDV IKKGLIHYGR DNQNLDILLF HEVLEYMSRI 2640
DRVLSFPGGS LLLAGRSGVG RRTITSLVSH MHGAVLFSPK ISRGYELKQF KNDLKHVLQL 2700
AGIEAQQVVL LLEDYQFVHP TFLEMINSLL SSGEVPGLYT LEELEPLLLP LKDQASQDGF 2760
FGPVFNYFTY RIQQNLHIVL IMDSANSNFM INCESNPALH KKCQVLWMEG WSNSSMKKIP 2820
EMLFSETGGG EKYNDKKRKE EKKKNSVDPD FLKSFLLIHE SCKAYGATPS RYMTFLHVYS 2880
AISSSKKKEL LKRQSHLQAG VSKLNEAKAL VDELNRKAGE QSVLLKTKQD EADAALQMIT 2940
VSMQDASEQK TELERLKHRI AEEVVKIEER KNKIDDELKE VQPLVNEAKL AVGNIKPESL 3000
SEIRSLRMPP DVIRDILEGV LRLMGIFDTS WVSMKSFLAK RGVREDIATF DARNISKEIR 3060
ESVEELLFKN KGSFDPKNAK RASTAAAPLA AWVKANIQYS HVLERIHPLE TEQAGLESNL 3120
KKTEDRKRKL EELLNSVGQK VSELKEKFQS RTSEAAKLEA EVSKAQETIK AAEVLINQLD 3180
REHKRWNAQV VEITEELATL PKRAQLAAAF ITYLSAAPES LRKTCLEEWT KSAGLEKFDL 3240
RRFLCTESEQ LIWKSEGLPS DDLSIENALV ILQIIGLKSW SRVCPFLIDP SSQATEWLKT 3300
HLKDSRLEVI NQQDSNFITA LELAVRFGKT LIIQEMDGVE PVLYPLLRRD LVAQGPRYVV 3360
QIGDKIIDYN EEFRLFLSTR NPNPFIPPDA ASIVTEVNFT TTRSGLRGQL LALTIQHEKP 3420
DLEEQKTKLL QQEEDKKIQL AKLEESLLET LATSQGNILE NKDLIESLNQ TKASSALIQE 3480
SLKESYKLQI SLDQERDAYL PLAESASKMY FIISDLSKIN NMYRFSLAAF LRLFQRALQN 3540
KQDSENTEQR IQSLISSLQH MVYEYICRCL FKADQLMFAL HFVRGMHPEL FQENEWDTFT 3600
GVVVGDMLRK ADSQQKIRDQ LPSWIDQERS WAVATLKIAL PSLYQTLCFE DAALWRTYYN 3660
NSMCEQEFPS ILAKKVSLFQ QILVVQALRP DRLQSAMALF ACKTLGLKEV SPLPLNLKRL 3720
YKETLEIEPI LIIISPGADP SQELQELANA ERSGECYHQV AMGQGQADLA IQMLKECARN 3780
GDWLCLKNLH LVVSWLPVLE KELNTLQPKD TFRLWLTAEV HPNFTPILLQ SSLKITYESP 3840
PGLKKNLMRT YESWTPEQIS KKDNTHRAHA LFSLAWFHAA CQERRNYIPQ GWTKFYEFSL 3900
SDLRAGYNII DRLFDGAKDV QWEFVHGLLE NAIYGGRIDN YFDLRVLQSY LKQFFNSSVI 3960
DVFNQRNKKS IFPYSVSLPQ SCSILDYRAV IEKIPEDDKP SFFGLPANIA RSSQRMISSQ 4020
VISQLRILGR SITAGSKFDR EIWSNELSPV LNLWKKLNQN SNLIHQKVPP PNDRQGSPIL 4080
SFIILEQFNA IRLVQSVHQS LAALSKVIRG TTLLSSEVQK LASALLNQKC PLAWQSKWEG 4140
PEDPLQYLRG LVARALAIQN WVDKAEKQAL LSETLDLSEL FHPDTFLNAL RQETARAVGR 4200
SVDSLKFVAS WKGRLQEAKL QIKISGLLLE GCSFDGNQLS ENQLDSPSVS SVLPCFMGWI 4260
PQDACGPYSP DECISLPVYT SAERDRVVTN IDVPCGGNQD QWIQCGAALF LKNQ 4314 
Gene Ontology
 GO:0045177; C:apical part of cell; IEA:Compara.
 GO:0035085; C:cilium axoneme; IEA:UniProtKB-SubCell.
 GO:0005829; C:cytosol; TAS:Reactome.
 GO:0030286; C:dynein complex; IEA:UniProtKB-KW.
 GO:0005794; C:Golgi apparatus; IDA:UniProtKB.
 GO:0005874; C:microtubule; IDA:UniProtKB.
 GO:0031512; C:motile primary cilium; IEA:Compara.
 GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0016887; F:ATPase activity; IEA:InterPro.
 GO:0003777; F:microtubule motor activity; IEA:InterPro.
 GO:0003774; F:motor activity; NAS:UniProtKB.
 GO:0019886; P:antigen processing and presentation of exogenous peptide antigen via MHC class II; TAS:Reactome.
 GO:0008105; P:asymmetric protein localization; IEA:Compara.
 GO:0006200; P:ATP catabolic process; IEA:GOC.
 GO:0001539; P:ciliary or flagellar motility; IEA:InterPro.
 GO:0042384; P:cilium assembly; IEA:Compara.
 GO:0007368; P:determination of left/right symmetry; IEA:Compara.
 GO:0009953; P:dorsal/ventral pattern formation; IEA:Compara.
 GO:0030326; P:embryonic limb morphogenesis; IEA:Compara.
 GO:0030900; P:forebrain development; IEA:Compara.
 GO:0007030; P:Golgi organization; IDA:UniProtKB.
 GO:0007018; P:microtubule-based movement; IEA:InterPro.
 GO:0016485; P:protein processing; IEA:Compara. 
Interpro
 IPR003593; AAA+_ATPase.
 IPR011704; ATPase_dyneun-rel_AAA.
 IPR026983; DHC_fam.
 IPR026815; DYNC2H1.
 IPR024743; Dynein_HC_stalk.
 IPR024317; Dynein_heavy_chain_D4_dom.
 IPR004273; Dynein_heavy_dom.
 IPR013594; Dynein_heavy_dom-1.
 IPR013602; Dynein_heavy_dom-2.
 IPR027417; P-loop_NTPase. 
Pfam
 PF07728; AAA_5
 PF12780; AAA_8
 PF08385; DHC_N1
 PF08393; DHC_N2
 PF03028; Dynein_heavy
 PF12777; MT 
SMART
 SM00382; AAA 
PROSITE
  
PRINTS