| Tag | Content |
|---|
| CPLM ID | CPLM-021638 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Chromobox protein homolog 8 |
Protein Synonyms/Alias | Polycomb 3 homolog; Pc3; hPc3; Rectachrome 1 |
Gene Name | CBX8 |
Gene Synonyms/Alias | PC3; RC1 |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 295 | RAAFLEAKGQGALDP | ubiquitination | [1] |
|
Reference | [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments. Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA. Mol Cell Proteomics. 2013 Mar;12(3):825-31. [ PMID: 23266961] |
Functional Description | Component of a Polycomb group (PcG) multiprotein PRC1- like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. |
Sequence Annotation | DOMAIN 11 69 Chromo.
MOD_RES 110 110 Phosphoserine.
MOD_RES 130 130 Phosphoserine.
MOD_RES 191 191 Phosphoserine.
MOD_RES 256 256 Phosphoserine.
MOD_RES 265 265 Phosphoserine.
MOD_RES 352 352 Phosphoserine. |
Keyword | 3D-structure; Chromatin regulator; Complete proteome; Nucleus; Phosphoprotein; Polymorphism; Reference proteome; Repressor; Transcription; Transcription regulation. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 389 AA |
Protein Sequence | MELSAVGERV FAAEALLKRR IRKGRMEYLV KWKGWSQKYS TWEPEENILD ARLLAAFEER 60
EREMELYGPK KRGPKPKTFL LKAQAKAKAK TYEFRSDSAR GIRIPYPGRS PQDLASTSRA 120
REGLRNMGLS PPASSTSTSS TCRAEAPRDR DRDRDRDRER DRERERERER ERERERERER 180
GTSRVDDKPS SPGDSSKKRG PKPRKELPDP SQRPLGEPSA GLGEYLKGRK LDDTPSGAGK 240
FPAGHSVIQL ARRQDSDLVQ CGVTSPSSAE ATGKLAVDTF PARVIKHRAA FLEAKGQGAL 300
DPNGTRVRHG SGPPSSGGGL YRDMGAQGGR PSLIARIPVA RILGDPEEES WSPSLTNLEK 360
VVVTDVTSNF LTVTIKESNT DQGFFKEKR 389 |
Gene Ontology | GO:0000792; C:heterochromatin; IEA:Compara. GO:0000790; C:nuclear chromatin; IDA:UniProtKB. GO:0035102; C:PRC1 complex; IDA:UniProtKB. GO:0000151; C:ubiquitin ligase complex; IEA:Compara. GO:0035064; F:methylated histone residue binding; IDA:UniProtKB. GO:0003727; F:single-stranded RNA binding; IEA:Compara. GO:0004842; F:ubiquitin-protein ligase activity; IEA:Compara. GO:0016574; P:histone ubiquitination; IEA:Compara. GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; IMP:UniProtKB. GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. |
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