UniProt Accession

 E1BL_ADE05; P03243; Q64827 

Genbank Protein ID

 M73260; X02996; X02996 

Genbank Nucleotide ID

 CAA26743.1; CAB40666.1 

Protein Name

 E1B protein, large T-antigen 

Protein Synonyms/Alias

 E1B 55 kDa protein; E1B-55K 

Gene Name

  

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Human adenovirus C serotype 5 (HAdV-5) (Human adenovirus 5) 

NCBI Taxa ID

 28285 

Lysine Modification

Position	Peptide	Type	References
104	GQGLKGVKRERGACE	sumoylation	[1, 2, 3]

Reference

 [1] SUMO-1 modification required for transformation by adenovirus type 5 early region 1B 55-kDa oncoprotein.
 Endter C, Kzhyshkowska J, Stauber R, Dobner T.
 Proc Natl Acad Sci U S A. 2001 Sep 25;98(20):11312-7. [PMID: 11553772]
 [2] Intranuclear targeting and nuclear export of the adenovirus E1B-55K protein are regulated by SUMO1 conjugation.
 Kindsmüller K, Groitl P, Härtl B, Blanchette P, Hauber J, Dobner T.
 Proc Natl Acad Sci U S A. 2007 Apr 17;104(16):6684-9. [PMID: 17428914]
 [3] Adenovirus type 5 early region 1B 55K oncoprotein-dependent degradation of cellular factor Daxx is required for efficient transformation of primary rodent cells.
 Schreiner S, Wimmer P, Groitl P, Chen SY, Blanchette P, Branton PE, Dobner T.
 J Virol. 2011 Sep;85(17):8752-65. [PMID: 21697482] 

Functional Description

  

Sequence Annotation

  

Keyword

 Alternative splicing; Complete proteome; Early protein. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 496 AA 

Protein Sequence

Gene Ontology

 GO:0009605; P:response to external stimulus; IEA:InterPro. 

Interpro

 IPR006717; Adeno_E1B_55K_N.
 IPR002612; Adeno_E1B_55kDa.
 IPR011050; Pectin_lyase_fold/virulence. 

Pfam

 PF01696; Adeno_E1B_55K
 PF04623; Adeno_E1B_55K_N 

SMART

  

PROSITE

  

PRINTS