| Tag | Content |
|---|
| CPLM ID | CPLM-021400 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Elongation of very long chain fatty acids protein 6 |
Protein Synonyms/Alias | 3-keto acyl-CoA synthase ELOVL6; ELOVL fatty acid elongase 6; ELOVL FA elongase 6; Fatty acid elongase 2; hELO2; Fatty acyl-CoA elongase; Long-chain fatty-acyl elongase; Very-long-chain 3-oxoacyl-CoA synthase 6 |
Gene Name | ELOVL6 |
Gene Synonyms/Alias | FACE; LCE |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 31 | QWMQENWKKSFLFSA | ubiquitination | [1] |
|
Reference | [1] Systematic and quantitative assessment of the ubiquitin-modified proteome. Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP. Mol Cell. 2011 Oct 21;44(2):325-40. [ PMID: 21906983] |
Functional Description | Condensing enzyme that catalyzes the synthesis of saturated and monounsaturated fatty acids. Highest activity toward C16:0 acyl-CoAs. |
Sequence Annotation | CARBOHYD 2 2 N-linked (GlcNAc...) (Potential). |
Keyword | Complete proteome; Endoplasmic reticulum; Fatty acid biosynthesis; Fatty acid metabolism; Glycoprotein; Lipid biosynthesis; Lipid metabolism; Membrane; Reference proteome; Transferase; Transmembrane; Transmembrane helix. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 265 AA |
Protein Sequence | MNMSVLTLQE YEFEKQFNEN EAIQWMQENW KKSFLFSALY AAFIFGGRHL MNKRAKFELR 60
KPLVLWSLTL AVFSIFGALR TGAYMVYILM TKGLKQSVCD QGFYNGPVSK FWAYAFVLSK 120
APELGDTIFI ILRKQKLIFL HWYHHITVLL YSWYSYKDMV AGGGWFMTMN YGVHAVMYSY 180
YALRAAGFRV SRKFAMFITL SQITQMLMGC VVNYLVFCWM QHDQCHSHFQ NIFWSSLMYL 240
SYLVLFCHFF FEAYIGKMRK TTKAE 265 |
Gene Ontology | GO:0005789; C:endoplasmic reticulum membrane; TAS:Reactome. GO:0030176; C:integral to endoplasmic reticulum membrane; IEA:Compara. GO:0016747; F:transferase activity, transferring acyl groups other than amino-acyl groups; IEA:Compara. GO:0019367; P:fatty acid elongation, saturated fatty acid; IDA:UniProtKB. GO:0042759; P:long-chain fatty acid biosynthetic process; IDA:UniProtKB. GO:0035338; P:long-chain fatty-acyl-CoA biosynthetic process; TAS:Reactome. GO:0019432; P:triglyceride biosynthetic process; TAS:Reactome. |
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